Application No. 13/378,
`Amendment dated May 26, 2015
`Reply to Office Action of February 13, 2015
`
`2
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`Docket N0.: Docket N0.: 89884(316697)
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`AMENDMENTS TO THE CLAIMS
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`1.
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`(Currently Amended) A blood sugar value estimation apparatus for non—invasively ealeul—ate
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`calculating a blood sugar value with time on the basis of an optical spectrum, with time, of a living
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`body, and a calibration model, said blood sugar value estimation apparatus comprising:
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`a calibration model creating means configured to create, using a processor, the calibration
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`model from a plurality of the calibration models or a plurality of datasets for creating the calibration
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`model, wherein
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`said blood sugar value estimation apparatus is configured to set, using the processor, a
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`reference spectrum by measuring a bio—spectrum of a person being tested, wherein said reference
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`spectrum and said bio—spectrum each respectively include an optical spectrum. and wherein
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`said blood sugar value estimation apparatus
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`includes an input port configured to
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`communicate with a measurement output member, the measurement output member configured to
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`receive a signal from a measurement probe,
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`said blood sugar value estimation apparatus is configured to calculate, using the processor, a
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`difference spectrum which is a difference between the reference spectrum and a measurement
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`spectrum which is measured in a time other than a time when the reference spectrum is measured,
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`wherein the measurement spectrum includes an optical spectrum,
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`said blood sugar value estimation apparatus is configured to make a change [[of]]i_n the
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`calibration model,—used—in—ealeul—atingg using the processor, according to a variation of the difference
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`spectrum over time, and wherein
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`said blood sugar value estimation apparatus is configured to estimate a blood sugar value
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`based on the measurement spectrum and the calibration model, or in response to a change in the
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`calibration model, the blood sugar value estimation apparatus is configured to estimate a blood
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`sugar value based on the measurement spectrum and the changed calibration model.
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`2.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 1, wherein said
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`blood sugar value estimation apparatus is configured to make a plurality of the changes of the
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`Application No. 13/378,
`Amendment dated May 26, 2015
`Reply to Office Action of February 13, 2015
`
`3
`
`Docket N0.: Docket N0.: 89884(316697)
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`calibration models, within a period for measurement, according to the variation of the difference
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`spectrum.
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`3.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 1, wherein the
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`blood sugar value estimation apparatus is configured to vary the reference spectrum which is used for
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`selection of the calibration model according to the variation of the difference spectrum after a certain
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`period of time.
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`4.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 2, wherein
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`when the blood sugar value estimation apparatus makes a plurality of the change of the calibration
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`models within the period for measurement, the blood sugar value estimation apparatus calculates a
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`first estimated blood sugar value on the basis of the calibration model which is previously used and
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`calculates a second estimated blood sugar value on the basis of the calibration model which is newly
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`employed,
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`the blood sugar value estimation apparatus is configured to make a bias correction such that
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`the first estimated blood sugar value and the second blood sugar value are coincided with each other,
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`and
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`then the blood sugar value estimation apparatus is configured to estimate the blood sugar value.
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`5.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 1, wherein
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`said blood sugar value estimation apparatus is configured to make the change of the calibration
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`model according to a development of a peak of a water in the difference spectrum.
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`6.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 1, wherein
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`said blood sugar value estimation apparatus is configured to make the variation of the calibration
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`model according to a development of a peak of a fat in the difference spectrum.
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`7.
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`(Previously Presented) The blood sugar value estimation apparatus as set forth in claim 1,
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`wherein
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`Application No. 13/378,
`Amendment dated May 26, 2015
`Reply to Office Action of February 13, 2015
`
`4
`
`Docket N0.: Docket N0.: 89884(316697)
`
`the blood sugar value estimation apparatus is configured to make the variation of the
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`calibration model according to a development of a peak of a water in the difference spectrum and a
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`development of a peak of a fat in the difference spectrum.
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`8.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 1, wherein
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`a plurality of the calibration models or a plurality of the datasets for creating the calibration model is
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`created by a numerical simulation,
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`the numerical simulation includes a disturbance having at least one of a variation of an optical
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`constant of water and a variation of an optical constant of fat.
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`9.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 5, wherein
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`the dataset for creating the calibration model corresponding to the development of the peak of
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`the water or the calibration model corresponding to the development of the peak of the water is
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`created by a numerical simulation,
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`the numerical simulation is set to simulate a propagation of light through skin tissue, the
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`numerical simulation includes a disturbance which is a variation of an optical constant, the variation
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`of the optical constant corresponds to at least a variation of an amount of water in the surface skin
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`tissue.
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`10.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 6, wherein
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`the calibration model corresponding to the development of the peak of the fat or the dataset for
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`creating the calibration model corresponding to the development of the peak of the fat is created by
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`the numerical simulation,
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`the numerical simulation is set to simulate a propagation of light through skin tissue, the
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`numerical simulation includes a disturbance which is a variation of an optical constant, the variation
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`of the optical constant corresponds to at least a variation of a concentration of fat in the subcutaneous
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`tissue.
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`11.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 6, wherein
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`AM 503134581
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`Application No. 13/378,
`Amendment dated May 26, 2015
`Reply to Office Action of February 13, 2015
`
`5
`
`Docket N0.: Docket N0.: 89884(316697)
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`said calibration model corresponding to the development of the peak of the fat or the dataset for
`
`creating the calibration model corresponding to the development of the peak of the fat is created by a
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`numerical simulation,
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`the numerical simulation is set to simulate a propagation of light through skin tissue, the
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`numerical simulation includes a disturbance which is a variation of the optical constant, the variation
`
`of the optical constant corresponds to at least a variation of scattering characteristic in surface skin.
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`12.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 1, wherein
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`said blood sugar value estimation apparatus comprises a light source, a measurement probe, and a
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`computing unit,
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`said light source is configured to emit light,
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`said measurement probe is configured to receive the light, said measurement probe is
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`configured to apply the light, received by the measurement probe, to the living body, when the light
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`applied to the living body is diffusely refracted in the living body, a diffusely reflected light is
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`developed,
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`said measurement probe is configured to receive the diffusely reflected light, said computing
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`unit is configured to extract the optical spectrum, of the living body, included in the diffusely
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`reflected light,
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`said computing unit comprises the calibration model creating means.
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`13.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 12, wherein
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`said computing unit comprises a measurement means and a blood sugar value estimation means,
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`said measurement means is configured to extract an optical spectrum of the living body included in
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`the diffusely reflected light,
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`said blood sugar value estimation means is configured to non—invasively calculate the blood
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`sugar value with time on the basis of the optical spectrum, of the living body, measured by the
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`measurement means with time and the calibration model.
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`Application No. 13/378,
`Amendment dated May 26, 2015
`Reply to Office Action of February 13, 2015
`
`6
`
`Docket N0.: Docket N0.: 89884(316697)
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`14. (Withdrawn) The blood sugar value estimation apparatus as set forth in claim 12, wherein said
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`calibration model creating means comprises a reference spectrum setting means, a measurement
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`spectrum setting means, a difference spectrum calculating means, and a calibration model changing
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`means,
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`said reference spectrum setting means is configured to measure the bio—spectrum of the
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`person being tested to set the reference spectrum,
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`said measurement spectrum setting means is configured to measure the bio—spectrum in a
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`time different from a time when the reference spectrum is measured, and set the measurement
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`spectrum which is defined by the bio—spectrum measured in the time different from the time when the
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`reference spectrum is measured as the measurement, said difference spectrum calculating means is
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`configured to calculate the difference spectrum which is a difference between the measurement
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`spectrum and the reference spectrum,
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`said calibration model changing means is configured to change the calibration model for
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`calculating according to the variation of the difference spectrum.
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`15. (Withdrawn) The blood sugar value estimation apparatus as set forth in claim 14, wherein
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`said measurement spectrum setting means is configured to set the measurement spectrum in
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`present as a first measurement spectrum, said measurement spectrum setting means is configured to
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`set the measurement spectrum of a previous time as a second measurement spectrum,
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`the difference spectrum calculating means is configured to calculate a first difference
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`spectrum which is defined by a difference between the first measurement spectrum and the reference
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`spectrum,
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`the difference spectrum calculating means is configured to calculate a second difference
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`spectrum which is defined by a difference between the second measurement spectrum and the
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`reference spectrum,
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`the difference spectrum calculating means is configured to calculate a variation of a
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`difference spectrum which is defined by a difference between the first difference spectrum and the
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`second difference spectrum,
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`Application No. 13/378,
`Amendment dated May 26, 2015
`Reply to Office Action of February 13, 2015
`
`7
`
`Docket N0.: Docket N0.: 89884(316697)
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`the calibration model changing means is configured to make the change of the calibration
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`model for calculating on the basis of the variation of the difference spectrum.
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`16. (Withdrawn) The blood sugar value estimation apparatus as set forth in claim 14, wherein
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`said measurement spectrum setting means is configured to set the measurement spectrum in
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`present as a first measurement spectrum, said measurement spectrum setting means is configured to
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`set the measurement spectrum which is measured in a previous time from the present time as a
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`second measurement spectrum,
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`the reference spectrum setting means is configured to measure the bio—spectrum of the person
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`being tested with every a first predetermined period of time after setting the reference spectrum again
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`to set the reference spectrum which is measured by the reference spectrum setting means,
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`the reference spectrum measurement means is configured to set a first reference spectrum which is
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`defined by the reference spectrum which is measured before a second predetermined period of time
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`from a time when said reference spectrum measurement means measures said first measurement
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`spectrum,
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`said reference spectrum measurement means is configured to set a second reference spectrum
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`which is defined by the reference spectrum which is measured by said reference spectrum
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`measurement means in a previous time from a time when the first reference spectrum is measured,
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`said difference spectrum calculating means is configured to calculate said first difference spectrum
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`which is a difference between the first measurement spectrum and the first reference spectrum,
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`said difference spectrum calculating means is configured to calculate a second difference
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`spectrum which is a difference between said second measurement spectrum and said second
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`reference spectrum,
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`said difference spectrum calculating means is configured to calculate a variation of the
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`difference spectrum which is a difference between the first difference spectrum and the second
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`difference spectrum,
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`said calibration model changing means is configured to change the calibration model for
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`calculating on the basis of the variation of the difference spectrum.
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`AM 503134581
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`Application No. 13/378,
`Amendment dated May 26, 2015
`Reply to Office Action of February 13, 2015
`
`8
`
`Docket N0.: Docket N0.: 89884(316697)
`
`17.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 16, wherein said
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`first reference spectrum is the reference spectrum which is measured before the first measurement
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`spectrum is measured,
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`said first reference spectrum is a latest reference spectrum among the reference spectrums which are
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`measured before the first measurement spectrum is measured.
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`18.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 13, wherein
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`said blood sugar value estimation means is configured to non—invasively calculate the blood sugar
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`value with time on the basis of a predetermined calibration model and the optical spectrum of the
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`living body which is measured by the measurement means with time when said difference spectrum
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`calculating means calculates no difference spectrum.
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`19.
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`(Withdrawn) The blood sugar value estimation apparatus as set forth in claim 13, wherein
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`said calibration model changing means is configured to create a predetermined calibration model
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`from a plurality of the calibration models or a plurality of the datasets for creating the calibration
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`model when said difference spectrum calculating means calculates no difference spectrum,
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`said blood sugar value estimation means is configured to non—invasively calculate the blood sugar
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`value with time on the basis of the predetermined calibration model and the optical spectrum, of the
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`living body, measured by the measurement means with time when the difference spectrum
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`calculating means calculates no difference spectrum.
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`20.
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`(New) The blood sugar value estimation apparatus of claim 1, further comprising:
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`the measurement probe; and
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`the measurement output member in communication with the measurement probe and the
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`input port of the blood sugar value estimation apparatus.
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`21.
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`(New) The blood sugar value estimation apparatus of claim 1, further comprising:
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`a display for displaying the estimated blood sugar value.
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