AMYLOID B MEASUREMENT METHOD, 13/521,683, No. 23-17-US-135216831AP1 (U.S. Pat. App. Jun. 4, 2015)

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`monomer
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`US- PGPUB;
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`US- PGPUB;
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`EPO; JPO;
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`US- PGPUB;
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`USOCR;
`EPO; JPO;
`DERWENT
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`US- PGPUB;
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`USOCR;
`EPO; JPO;
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`US- PGPUB;
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`EPO; JPO;
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`US- PGPUB;
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`EPO; JPO;
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`US- PGPUB;
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`irrigation
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`ADJ
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`EPO; JPO;
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`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`
`
`2015/05/31
`
`23:42
`
`2015/05/31
`
`23:42
`
`2015/05/31
`
`23:42
`
`2015/05/31
`
`23:42
`
`2015/05/31
`
`23:42
`
`2015/05/31
`
`23:42
`
`2015/05/31
`
`23:42
`
`2015/05/31
`
`23:43
`
`2015/05/31
`
`23:43
`
`
`
`
`
`L73
`
`L74
`
`L75
`
`L76
`
`L77
`
`L78
`
`L79
`
`L80
`
`L81
`
`
`
`
`
`10
`
`2435
`
`656
`
`43
`
`63
`
`32
`
`36695
`
`5799
`
`L72 and L15
`
`irrigation solution
`
`L74 and L68
`
`L75 and L15
`
`L75 and L7
`
`L76 and L59
`
`L77 and L59
`
`fibril
`
`L80 and L7
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`
`DERWENT
`
`
`
`6/1/20151:53:22 AM
`
`C:\Users\cwang\Documents\EAST\Workspaces\13521683.wsp
`
`Page 8
`
`

`EAST Search History (Prior Art)
`
`L81 and L74
`
`ADJ
`
`ON
`
`2015/05/31
`
`23:43
`
`L82
`
`L83
`
`L84
`
`L85
`
`L86
`
`L87
`
`L88
`
`L89
`
`L90
`
`L91
`
`
`
`
`
`77
`
`301
`
`170
`
`33
`
`66
`
`270
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`L81 and L16
`
`L83 and L15
`
`nasal irrigation
`
`L74 and L14
`
`L86 and L7
`
`L87 and fibril
`
`L74 and fibril
`
`L89 and L15
`
`L28 and L14
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`
`
`2015/05/31
`
`23:43
`
`2015/05/31
`
`23:43
`
`2015/05/31
`
`23:43
`
`2015/05/31
`
`23:43
`
`2015/05/31
`
`23:43
`
`2015/05/31
`
`23:43
`
`2015/05/31
`
`23:44
`
`2015/05/31
`
`23:44
`
`2015/05/31
`
`23:44
`
`
`
`
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`
`DERWENT
`
`
`
`6/1/20151:53:22 AM
`
`C:\Users\cwang\Documents\EAST\Workspaces\13521683.wsp
`
`Page 9
`
`

`EAST Search History (Prior Art)
`
`L92
`
`41
`
`L91 and fibril
`
`ADJ
`
`ON
`
`2015/05/31
`
`23:44
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`
`
`2015/05/31
`
`23:44
`
`2015/05/31
`
`23:44
`
`2015/05/31
`
`23:44
`
`2015/05/31
`
`23:44
`
`2015/05/31
`
`23:44
`
`2015/05/31
`
`23:45
`
`2015/05/31
`
`23:45
`
`2015/05/31
`
`23:45
`
`2015/05/31
`
`23:45
`
`
`
`
`
`
`
`L93
`
`L94
`
`L95
`
`L96
`
`L97
`
`L98
`
`L99
`
`L1 00
`
`L101
`
`
`
`41
`
`16
`
`30342
`
`882
`
`40
`
`29
`
`L92 and L7
`
`brain irrigation
`
`L94 and L7
`
`L94 and L85
`
`living tissue
`
`L97 and L16
`
`L98 and L7
`
`L99 and L14
`
`L99 and L15
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`
`DERWENT
`
`
`
`6/1/20151:53:22 AM
`
`C:\Users\cwang\Documents\EAST\Workspaces\13521683.wsp
`
`Page 10
`
`

`EAST Search History (Prior Art)
`
`L1 02
`
`37
`
`L99 and L68
`
`ADJ
`
`ON
`
`2015/05/31
`
`23:45
`
`
`
`L1 03
`
`L1 04
`
`L1 05
`
`L1 06
`
`L1 07
`
`L1 08
`
`L1 09
`
`L110
`
`L111
`
`
`
`12
`
`2466
`
`41993
`
`338
`
`270
`
`111
`
`70
`
`10
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`
`
`2015/05/31
`
`23:45
`
`2015/05/31
`
`23:45
`
`2015/05/31
`
`23:45
`
`2015/05/31
`
`23:45
`
`2015/05/31
`
`23:46
`
`2015/05/31
`
`23:46
`
`2015/05/31
`
`23:46
`
`2015/05/31
`
`23:46
`
`2015/05/31
`
`23:46
`
`
`
`
`
`L99 and L80
`
`artificial cerebrospinal fluid
`
`amyloid
`
`L104 and L105
`
`L106 and L15
`
`L106 and L8
`
`L108 and L13
`
`L109 and L14
`
`L110 and L80
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`
`DERWENT
`
`
`
`6/1/20151:53:22 AM
`
`C:\Users\cwang\Documents\EAST\Workspaces\13521683.wsp
`
`Page 11
`
`

`EAST Search History (Prior Art)
`
`L112
`
`3064
`
`amyloid fibril
`
`ADJ
`
`ON
`
`2015/05/31
`
`23:46
`
`
`
`L113
`
`L114
`
`L115
`
`L116
`
`L117
`
`L118
`
`L119
`
`L1 20
`
`L121
`
`
`
`21
`
`33
`
`21
`
`33
`
`50
`
`14
`
`65
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`
`
`2015/05/31
`
`23:46
`
`2015/05/31
`
`23:46
`
`2015/05/31
`
`23:46
`
`2015/05/31
`
`23:46
`
`2015/05/31
`
`23:47
`
`2015/05/31
`
`23:47
`
`2015/05/31
`
`23:47
`
`2015/05/31
`
`23:47
`
`2015/05/31
`
`23:47
`
`
`
`
`
`L112 and L104
`
`L112 and L15
`
`(artificial cerebrospinal fluid) and amyloid
`fibril
`
`L112 and L15
`
`L104 and L97
`
`L117and L15
`
`L97 and L15 and L16
`
`nasal irrigator
`
`L120 and L7
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`
`DERWENT
`
`
`
`6/1/20151:53:22 AM
`
`C:\Users\cwang\Documents\EAST\Workspaces\13521683.wsp
`
`Page 12
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`

`EAST Search History (Prior Art)
`
`L1 22
`
`26
`
`L22 and L1 1
`
`ADJ
`
`ON
`
`2015/05/31
`
`23:47
`
`
`
`L1 23
`
`L1 24
`
`L1 25
`
`L1 26
`
`L1 27
`
`L1 28
`
`L1 29
`
`L131
`
`L1 32
`
`
`
`18620
`
`379
`
`222
`
`57
`
`8187
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`
`
`
`
`2015/05/31
`
`23:47
`
`2015/05/31
`
`23:47
`
`2015/05/31
`
`23:47
`
`2015/05/31
`
`23:47
`
`2015/05/31
`
`23:47
`
`2015/05/31
`
`23:48
`
`2015/05/31
`
`23:48
`
`2015/06/01
`
`00:47
`
`2015/06/01
`
`00:49
`
`
`
`L120 and L14
`
`nostrils
`
`L124 and L7
`
`L125 and L8
`
`L126 and L1 1
`
`L127 and L12
`
`(artificial cerebrospinal fluid) and (brain
`irrigation)
`
`L85 and L7
`
`nasal mucosa
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`
`DERWENT
`
`
`
`6/1/20151:53:22 AM
`
`C:\Users\cwang\Documents\EAST\Workspaces\13521683.wsp
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`Page 13
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`

`EAST Search History (Prior Art)
`
`L1 33
`
`521
`
`I132 and I7
`
`ADJ
`
`ON
`
`2015/06/01
`
`00:49
`
`
`
`L1 34
`
`L1 35
`
`L1 36
`
`L1 37
`
`L1 38
`
`L1 39
`
`L141
`
`L1 42
`
`L1 43
`
`
`
`44
`
`31
`
`27
`
`14
`
`170
`
`33
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`OR
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`
`
`ON
`
`ON
`
`ON
`
`ON
`
`OFF
`
`ON
`
`ON
`
`ON
`
`ON
`
`
`
`
`
`2015/06/01
`
`00:49
`
`2015/06/01
`
`00:50
`
`2015/06/01
`
`00:50
`
`2015/06/01
`
`00:52
`
`2015/06/01
`
`00:55
`
`2015/06/01
`
`00:57
`
`2015/06/01
`
`01:15
`
`2015/06/01
`
`01:19
`
`2015/06/01
`
`01:19
`
`
`
`I133 and I12
`
`I133 and I11
`
`I135 and irrigation
`
`I20 and I15
`
`("20080199879").PN.
`
`I85 and ELI SA
`
`(irrigation solution) and ELISA and (nasal
`mucosa)
`
`(irrigation solution) and ELISA
`
`H42 and I7
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`
`DERWENT
`
`
`
`6/1/20151:53:22 AM
`
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`Page 14
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`

`EAST Search History (Prior Art)
`
`
`L144
`
`130
`
`ADJ
`
`ON
`
`2015/06/0101:25
`
`
`
`L145
`
`L146
`
`L147
`
`L148
`
`L149
`
`L150
`
`L151
`
`L152
`
`L153
`
`
`
`2
`
`0
`
`0
`
`429
`
`207
`
`69
`
`61
`
`1
`
`14
`
`
`
`
`
`OR
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`
`
`OFF
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`
`
`
`
`2015/06/0101:25
`
`2015/06/01 01:26
`
`2015/06/01 01:26
`
`2015/06/01 01:27
`
`2015/06/01 01 :27
`
`2015/06/01 01:27
`
`2015/06/01 01:27
`
`2015/06/01 01:27
`
`2015/06/01 01:31
`
`
`
`"7654997" USPGPUB;
`USPAT;
`USOCR;
`EPO;JPO;
`DERWENT
`
`("7654997").PN. USPGPUB;
`USPAT;
`USOCR;
`EPO;JPO;
`DERWENT
`
`tissue irrigation and amyloid and ELISA USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`tissue irrigation and amyloid USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`irrigation and amyloid USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`irrigation and amyloid and ELISA USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`I149 and concentrate USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`I150 and nasal USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`I150 and nasal mucosa USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`I149 and I11
`
`USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`
`DERWENT
`
`
`
`6/1/20151:53:22 AM
`C:\Users\cwang\Documents\EAST\Workspaces\13521683.wsp
`
`Page 15
`
`

`EAST Search History (Prior Art)
`
`
`L154
`
`1
`
`ADJ
`
`ON
`
`2015/06/01 01:32
`
`I149 and I12 USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`irrigated fluid USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`I155 and I7 USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`I155 and ELISA USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`protein extraction USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`I158 and irrigation USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`I159 and ELISA USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`I160 and I11
`
`USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`I160 and I12 USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`
`
`L155
`
`L156
`
`L157
`
`L158
`
`L159
`
`L160
`
`L161
`
`L162
`
`L163
`
`
`
`181
`
`0
`
`1
`
`14301
`
`298
`
`86
`
`12
`
`0
`
`4
`
`
`
`
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`ADJ
`
`
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`ON
`
`
`
`
`
`2015/06/01 01:32
`
`2015/06/01 01:33
`
`2015/06/01 01:33
`
`2015/06/01 01:33
`
`2015/06/01 01:33
`
`2015/06/01 01:34
`
`2015/06/01 01:34
`
`2015/06/01 01:34
`
`2015/06/01 01:48
`
`
`
`I155 and ultrafiltration USPGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`
`DERWENT
`
`
`
`6/1/20151:53:22 AM
`C:\Users\cwang\Documents\EAST\Workspaces\13521683.wsp
`
`Page 16
`
`

`EAST Search History (Prior Art)
`
`L1 64
`
`38
`
`
`
`I149 and ultrafiltration
`
`
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`
`
`
`L1 65 2015/06/01 01:50 16 I150 and ultrafiltration DERWENT
`
`
`
`US- PGPUB;
`USPAT;
`USOCR;
`EPO; JPO;
`DERWENT
`
`
`
`ADJ
`
`ADJ
`
`ON
`
`ON
`
`
`
`2015/06/01 01:49
`
`
`
`
`
`6/1/20151:53:22 AM
`
`C:\Users\cwang\Documents\EAST\Workspaces\13521683.wsp
`
`Page 17
`
`

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