(12) $§E¢Tfifi%ffi9l:§’3b\ffiffi éi’LT:EI|3?§HjJEE
`
`(19) fifiy’fiflfififififi’ffil‘fiéfifi
`
`l
`
`% |||||||||||||||||||||||||||||||||||||IHEILILIIIIIFIIEQII|||||||||||||||||||||||||||||||||
`Ew$fig
`.
`&
`(43)
`[fi/Afifi El
`2013 E 3 )5! 7 EI(07.03.2013) WI Po I F, CT
`
`(10)
`
`“4&9;
`
`7%
`
`WO 2013/031137 A1
`
`(51)
`
`IBfiEfiE‘Ffii‘E:
`A61N 5/06 (2006.01)
`F21V7/09 (2006.01)
`F21 VII/08 (2006.01)
`Ilfi—Efllfififiv?
`IBfifllfiEEl:
`==
`(25) Iflfifilfifiwaafiz
`(26)
`Iflilfi’AFafiwEEE:
`
`(21)
`(22)
`
`F21V11/12 (2006.01)
`F2/Y/oI/oo (2006.01)
`
`PCT/JP2012/005243
`2012 Eli 8 )5] 22 EI(22.08.2012)
`=
`EIZ’SEE
`32:3,;
`
`(81) IEEI (fifiwfiurfifl U . é’CODEi‘EODI Wffi
`3E1)“ Flag); AE, AG, AL, AM, Ao, AT, AU, AZ, BA,
`BB, BG, BH, BN, BR, Bw, BY, Bz, CA, CH, CL, CN,
`CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES,
`iisl 1%]: 123GB £151 G141; Elli/[13:’ 11:;LPARLICULKDLIR II}:
`LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX,
`MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT,
`QA, Ro, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST,
`SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ,
`VC, VN, ZA, ZM, ZW.
`
`(30) (EiIE?—9:
`##JEE 2011—191348 2011 E 9 J5] 2 El (02.09.2011)
`
`JP
`
`(71)
`
`(s4) IEEEI (Efimtmfiflu . grabfiifimmififié
`EE fifif‘n‘fi): ARIPO (BW, GH, GM, KE, LR, LS, MW,
`fllfifik (filéI 55% < firmflfiiltamt): /\°d-
`MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), 1—5 9
`‘J 2 v ’7 Haitéiii (PANASONIC CORPORATION)
`7 (AM, AZ, BY, KG, KZ, RU, TJ, TM), El — I: v /\°
`[JP/JP]; ? 5718501 I BEE-T F'EJ 32 FE it $313; 1 O 0
`(AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR,
`6 EH}. Osaka (JP).
`GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT,
`\
`.
`NL, NO, PL, PT, Ro, RS, SE, SI, SK, SM, TR), OAPI
`(72) fiflfi'fi; 353:0
`(75) fififi'fi/wlfifik GEEK/aura)?” Xflgg
`$5’3’fS’fSfi CI, CM, GA, GN, GQ, GW, ML, MR,
`(DAIJO,Kazuhir0).
`~$HAFifiiéE .
`_
`,
`,,
`(74) (HEX: WE;
`ififii, 91*(NA1’1‘0,HirokietaL);
`1 \
`» A 5; =5
`;
`10-”
`5718501 fifflifi'fi‘F‘fiEFfifiiF‘fiE1 O O 6
`1113/ — Iflfisfifiifi‘é? (%$’§§E21%(3))
`7' ‘J 2 y bfléitfiitm Osaka (JP).
`
`$1193
`
`(54) Title: PHOTORADIATION DEVICE AND PHOTORADIATION THERAPY/PROPHYLAXIS DEVICE COMPRISING
`SAME
`
`(54) fiEHODaET/F : fi'fififié‘fgfiisdflfi%hélfiitfi'fififi§fifilfi - Tlllb'gfi
`
`[I4]
`
`Wfix‘mz/%
`
`
`
`(57) Abstract: This photoradiation device comprises a light emission unit Which projects irradiation light, a reflection unit Which re-
`flects the irradiation light, and a light guide unit which guides the reflected irradiation light to a subject to be irradiated. The light
`guide unit further comprises a first light guide face and a second light guide face. The reflection unit further comprises a first reflec -
`tion unit which reflects a portion of the irradiation light to the first light guide face, a second reflection unit which reflects entering
`light to the second light guide face, and a third reflection unit formed from a main body unit Which disposes a translucent unit and
`which reflects a portion of the remaining irradiation light to the second reflection unit as the entering light. The translucent part side
`of the third reflection unit is positioned oblique to the light emission unit, and the third reflection unit further comprises a configura-
`tion wherein the closer the translucent unit of the third reflection unit is to the light emission unit, the greater the quantity of translu -
`cent light of the irradiation light. A photoradiation device is thus implemented Which illuminates a plurality of irradiation surfaces
`With a single light emission unit.
`
`(57) Efi'fl:
`
`[fifi’fi]
`
`
`
`wo2013/031137A1|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
`
`

`

`VV()20L&®311371A1HMWWWMNWMWWWWWMWWWMWWWWWWW
`
`%Hfl&fl%
`
`Efiabmm
`
`fimfififié
`§1~1#?
`
`t§2%%fi
`
`éfiwiflm
`
`fififiéfl?
`
`fitfifiufi
`
`fififififii
`
`tztflfié
`
`~leLo
`
`figfifit:
`
`fififiwmn
`
`éfiétfit
`
`mtfi$é$
`
`t§%WhU
`
`mfitfi“
`
`fibémfi1
`
`fixfiaso
`
`t
`¢L§%%EM%¢éfitflt m%
`thEfiiéo%LT %%
`
`%&t
`
`
`‘E@Aflmfa,
`Jfifififio
`‘1Eflfifi
`Eumfiagé
`
` fifl$fi$H6_Em?fiwmfifi
`
`

`

`WO 2013/031137
`
`1
`
`PCT/JP2012/005243
`
`% EHJE
`
`fiwwfifl:
`
`%m%§fi 3$U%h%fizk%mW6% ¥M§E
`
`EEEE
`
`[0001]
`
`EEWH‘WEEWEEEE—EEEEEEEEEEEiEB$U%mEEZ
`
`EEEEEE- EEEEEEEEE
`
`”EEFIE
`
`[0002]
`
`EEmeEEEEEEékwwEESEE*EtLT EaatwfiEEé
`
`h’cméo With —$§ELCE3E$ mrEmew @Eéfifififififlmcfi L’C
`
`\EMKE%?étw®%fiWMEVKKfiE%iEfiEé
`
`[@003]
`
`Eh EEWMEEALEEEiEtLT EIEEE— EEXA— X
`
`IJ\§.E4I:7Z£<‘:“OJE'€2W:FEL3’C\ EflfififififlfifififififiébfizEéEfii’L’cmé (WUZ
`
`thk ¢E§$§Zfifi1 725%)
`
`o
`
`[0004]
`
`CIEEFB'IEH t:EJzT<tS:I/L’CL\%)EEJQEEEJEEE‘EHEEELE HEELCEWU’STU‘:
`
`@fi®%fifi$fifibffi%bffififimc¥fifiwfiflfifiwt\ma”
`
`EJI/ODPEE'DEZISUDJiNfiU ($43M)
`
`tcfirfifl L’CEEE'STL :Zfififlfiwfifim‘v— |\
`
`b flKEi/QEJI/tJiErfiV— |~ twfi—fiflfififimcmfié m7”:%fi‘fifif$c‘: éfiié
`
`o Jifia‘v—th %%EB¢J\6E’E1’L5£C Lfdfi‘o‘c HKESIIQEJI/twflfififibfifi
`
`<E6(WEE)$5K\MENE»EELTEHTEE$nTvEO
`
`[0005]
`
`% L’C Eibflfijéifilfifififlfififiétat‘ %%E5b\l‘ofifilfin‘éhttfilfin‘fi'fiéfifia‘y
`
`—FEE%$fifflflm?wEl%$fiéoZ®t§\%%$#5flhéfi
`
`bfcbfa’C‘ EEU‘D—hbl‘ofififiél/{EJI/E’GO)
`
`(E’EF'E) EE'E’EbR Edna,
`
`9E U‘ %%EBb\BJ§%flL°/— |\ t:fi§%fi$mé§fifil%fifi'fi®fi'fifl§fib‘fi < 72%) L:
`
`9111‘ éfififl‘i‘fiwfifia‘v— |\7b\€>$flfifi5(/\°?~II/E’Gd)i‘fifl%§7bfi
`
`EEK 72:50
`
`LTbeO'C‘
`
`fifi‘fififm‘l‘ofifia‘v— Ix E’Gwflfififitfifia‘D— hb‘BJIJKEQ/{EJI/
`
`E’GODEE'E'Et fifil—ttté J: 5 tcfififiv— |\ EEEE L’C fifi'fififlb‘ BJ§§W~>
`
`—htEE$nTEENE»EELEEEEMEEwEEEfi—EEEEE5
`
`

`

`WO 2013/031137
`
`2
`
`PCT/JP2012/005243
`
`LCEJfijiiféL/TVéo
`
`[@006]
`
`Diuxfixwaflfifiwflfififiémxfififlfiaflnftxmafifi
`
`)InbV‘ofifiEa‘éméfiflfia‘fi'fiwfififibWEi—F Mime]: 5 LC‘ %fi'fififi7§\l‘o)§%fl~>— I\
`
`EM%3%§M%%®%%EE%E?5Z£E$U‘MflNfiwiwfififi
`
`E—Emé$5ufiflfimrméo
`
`[0007]
`
`Lfib‘iEEEWfiwflfififiém‘mfi%%%—3mfiafi%?éc
`
`tmw$mfimbfv50%®tw‘mzwmfi%W#iw%é‘%®$t
`
`infitwfiEEfiE$tCfifififi¢éEL$ $0Tfifit:%h%’h$filrfijéfif\ E
`
`flfifififlfiw%éémfibmwnwmamvo
`
`[0008]
`
`ififimvm\m&fifiw%M%\figlzw¥—#Em¢amawai
`
`fifioko%:?‘—O®%%fifi\wifiiwfififlfiwéfiwfi%fié
`
`fi—Efi%?§é%fi%%fifi£fi\fi<¥infméo
`
`fifififiim
`
`fiaxm
`
`[0009]
`
`%¥Iflh%fi2009—282725%Qfi
`
`%%ow§
`
`[0010]
`
`iafifiéfimiétwn\$%wwfifi%%fim\M%%&M%¢é%
`
`fi$t\fl%%éfi%?éfi%flt\E%fl#6fi%$hkm%%éfifi%
`
`WtCiE—fi‘fi?%>i§rfi‘fifif5t\ Efiiéo % L’Cx Efi‘fifimatfi1ODE—fi‘fifitfi2 0)
`
`Efi‘fific‘: 722% L/\ Efififimifi 1 @Efi‘fifitififilfifl‘fi‘fiOD—E‘Béfififitéfi1 ODE
`
`fifl‘fifltx % 2 @Efi‘fifitllfififi‘fiéfififitéfi 2 @EEU‘E‘BcE‘ % 2 @Efifl‘fiffit:
`
`fifilfifl‘fi‘fiwfiU OD—E‘Bélfifl‘fi‘fic‘: L’CEEfifi'éEEE‘BEEQHEZMZI-‘E‘fflfi672%)
`
`% 3 @Jififi‘ffit EE?‘%>° '5 4‘9 LC‘ % 3 @fiQfifiBtiEiflfiMflUfi%fi‘fifiMflUtdlzfi
`
`fibffififihétt%fl‘$3®E%%®Efi%m%%%flfifi<figfl
`
`Qfl‘fi‘fiwfififi‘fiibfigflfl?éfififii7&fii’CL\%>0
`
`[0011]
`
`CMK$U\10®fifi$fi5fl%$hkfl%%fi‘fi1®§fifitfi2
`
`wfififitufi§mfimfinéoDiU\19®%%%T\E&®§%EE
`
`M%%EM%LT~mifiiflfwfigéfiiéfifi%%éfififlfi%ié
`
`

`

`WO 2013/031137
`
`3
`
`PCT/JP2012/005243
`
`CtfiTEéo36E:E3®EEEQEEEE$U:E1®EEEEBH
`
`EEEEEEi’E—EEEEEEE’ tfi’GEE
`
`[0012]
`
`E7: EEHJELE LEEEEEEEEEbEEC‘KTLEMEEEEE1EUJEEEEB1E
`
`[EEEEC ta; :EEELEEEEEEEEEE- EEEEETEDT
`
`: EEEBE EEKEC‘I :l’L’CiEfi‘tEBEiED ’CEE‘C‘S EEEKEEEUDE‘EEELEEEEE
`
`n EEEBb‘BMEEC‘SméMEEfi'fiwfiB: EE754‘5 6 6.
`
`5 n mLLUC7 8 o
`
`n mDIFODE’EIPEODMEJ‘EEEiECY EEEEEEEBE: C‘Il‘olCEi: SEESE
`
`EEBEE‘ECS EEEEJ‘EEEEUJEEEEBElCEE‘EE’lE/SBZEELCCVEO
`
`[0013]
`
`:nlCctU fiéE'lEET/r HJ/r/ODEEEEBEULT WUlefi‘fiéE'EEEw
`
`IEEEEBEEEttEl; IEEEIEUDEEEEEE: EfclatEIBEUT‘EEo
`
`IEUJEEEEEHH
`
`[@014]
`
`[I1AJI1 Ali EEEHODEEECD ’“ElCEE/EE;EODEEWE‘EH’EEEI
`
`E (h V E G F) ODEEEEEEO‘S7UDI’GEEO
`
`[II1311 Blat: EEEHUJEEEUJ éElCFéEEECtODEEEE’r #734 y
`
`wEEEEEEfiE7®IEEEO
`
`[IZJIZlat EEEEOJEEEUJ "ElCEEJ‘uEEE/EE EBEEEEUJEUEIIIEIEEI
`
`(“EEO
`
`[I3JI3lat HEEUJE/UlCEéa‘uEEEE- EBEEEEUJEEEEIEEE
`
`[IMI4E EEEw EéEKEEEEEEE- EEEE EwEEEwEEIT
`
`E5ESO
`
`[I5A1I5Alzt EEECD ’“ElClEéEEEEE EBEEEEUJESCDEEEB
`
`EZTTB‘IEEI’C‘EEO
`
`[5315 Blgt: EEEU) ZElJfizéa‘uEE/EE EBJEEEEODE3UDJ§EEB
`
`@EEEEEEBHEEEBEEEEEI’GEEO
`
`[II6]6lat: EEEO) é‘ilCEEJ‘EEEEE- EBEEEElClEL\7‘:/\‘/I<‘/\°X
`
`74)»!3/ (EEEEEB) (DEEEODEEEEEEEO‘E7(JD-E3350
`
`[ll7AJ7 Ali: EEEOD 2E®EE4§MCEEEEE>EE- EBEEEEOJEE
`
`

`

`WO 2013/031137
`
`4
`
`PCT/JP2012/005243
`
`%fi®%1®§%fi#B%%SMEM%%®Wfi%EEBU5%Efi$ET
`
`$350
`
`[”73] 7 BEL filifi’fiwfiéfiéwé‘éfi’fifiutcfiéfi‘fifififia‘ififlafi - $BE§EOJ7EZE§
`
`fififiwfi 2 ODE—fifib‘ Fafifififi’é httfilfififi'fiw’fifififififitcaa b‘éfififififilf“
`
`Ewéo
`
`[I8A]I 8 A1; 5137:5803 éiiéwtt$§1§|11c1§é¥fifififififififi - $Bfi$€f§®7flzflfi
`
`fin‘fimfi 1 wiEfi'fiEb‘ l‘ofififia‘fi mtfifilfin‘fi'fiwmfififiafitcaa Héfififififil’c
`
`£80
`
`[I8IB] 8 Boat
`
`fig‘éfi’fia) Zfiwttfis‘tfimdnfiéfi‘tfififia‘ififi - $Bfi§fi®¥flzfifi
`
`%fi®%2®§%fi#Bfi%$hkfl%%®fifi%finawéfififififlfi
`
`Ewéo
`
`[I9A]I 9 A 12L
`
`7 A waEfifimtl 8 A0tt$§1§fltc1%8fi‘fififi%fiifi$§ - $193
`
`fifiwfififififiltcavt $1 @gfilfifib‘gfififijfiTLTCfiKQ?%®*EZ§fi§ETE
`
`w1fifitfifi§t®l§§1§éfi¢7570>IT°$>60
`
`[”93] 9 B can
`
`7 swag/mu:- 8 Bwttfiwfimanfiéa‘tfififififififi - $193
`
`”filfiwfififififil tcaau’c % 2 @fifi‘fifiifi l‘ofififia‘fi nrcmva'awwfiam
`
`mififitfififitwfiafifiéfifififi7OJI’C‘WJéo
`
`[HWMH1OAH‘$%%®$fi®Zfifi%é%%%%fi'¥%§fi®fi®
`
`1§U®%3 ®EQ7EB7izT<fiEEITWJ5O
`
`[I1IOBJ1 0 Boat Zifififiwgfiéfi’fia) 9%1:1%5%fifi%7$fi“§ - $573§§E03$ 5
`
`LCEUOD1§UOD%3 (DJifim‘fiB‘ézT:?IEEIF%%>O
`
`fiflfié$m9§fcw®fi3fi§
`
`[0015]
`
`LLL‘F‘ $%HH®$EE® éfi‘étcaab‘éfi‘fifififin‘fifib‘;0%mé1fiztfi'fifififia‘
`
`361%? - $Bfié§f§1COLVC Ifiééfififibmb‘gfifififla‘éo 7:38 2833550931?
`
`%K$91$%%#RE$Méfiwvmmmo
`
`[0016]
`
`(3358091131953)
`
`LX‘FL; Zlifififiw$fitfi® 3831:9511éfifi§9¢%fia$v%m&fizkfififi
`
`377381»? - $Bfié€f§tcvmt
`
`IEEflLVCEFEEH¢60
`
`

`

`WO 2013/031137
`
`5
`
`PCT/JP2012/005243
`
`[@017]
`
`mbmfixE%E®%%K5Hé%%%fifi'$W§Eflfi$émflté
`
`fifi'iifi’f |\jJ’f‘/0)i§}Ji§iCDL\’C\ I1 AtIi BEFHU’CEi'fififlj'éo
`
`[0018]
`
`fifififi4hh4ym‘$WW®%%mflflfi%fi&fl5fififi9yfib
`
`waiffiW’GWJéfi’f FW4‘JOD—ii’633éo ##ii‘ fifi'iiiT’f |\73/f‘/i3t‘
`
`iiZiSPiiCii/Vflfiéfifiilfiégl§Elifin¥t L’CF'asEJfi LA ifi'iiiBVOEI
`
`77—9%$fi‘i$ib£fll%fii§ifiiflfifl7b\stfiflifii’téo
`
`[0019]
`
`EiZiSE’JiCWUfifiLét‘ fiéfi'iifi'f I‘m/{Vida %%fi7fit5’6$§fl$m7zfi
`
`$W®fififi#4hh4yfi%é\(h)VEGF(fl%W&fl%EEfl¥
`
`\ Vascular Endothel ial Growth Facto
`
`r) \ TNFa (H§%i§%-¥\
`
`t umo r nec ros is
`
`fact
`
`or—a)‘
`
`IL—1B(’f‘/’9—El’f=\=‘/16‘ interleukin
`
`—1B)\
`
`IFN’V (’f‘J’9—7IEI‘J7‘ interferon7)\ |
`
`L—6 (’{V’9—EI43FV6‘ interleuk i n—G)‘
`
`lL—12
`
`a (/f‘J’F—El’f$y1 2a‘
`
`i n‘te r
`
`| euk i n—12a) fgfi‘bffi
`
`fi$M%o
`
`[0020]
`
`%L/’C~ fifi'iifi’f Fri/{Vii iiziSiCBV’Cé’rEyfiEUNT’f Fh/beWE
`
`fifat?‘y |\'7—0 E9¥3EEL173275€5\
`
`$42!“: bffifi'iiwfiéifi'iiéfiifi?é
`
`OOEU\%EH#4ht4yH\fib<flfifl6§$$h\%fiémfli
`
`é?fi'i$€fi?éfifiéfi'i$fi4 F734>t031§577x7bffifihéltitéibk it
`
`311':
`Efififiwiflfiflflfififiifigéfiiflé fiéo
`
`[@021]
`
`Efixfififififi4hb4yw—DfifiélL—4(4V5—D4$y1
`
`a\interleukin—4)E\fifififi4hb4v®§$%mfl¢
`
`é’i‘fiifimmlctii‘ fifififatc‘i‘b‘lbéléufifi L’CL\%)0
`
`[0022]
`
`tZZJb‘I ZEJEEH'JJEEALJ‘
`
`ififlfi‘éfi‘iifi’f |~734‘/7’J‘I WUiiififiIE-EEb‘B
`
`fi%$héfi%%(m%%)0%EwfiEThVEGF®E$§#\%mm
`
`flwififittt$§L1§fi<iiflfiflfihélt7éfifiLEO
`
`[0023]
`
`QWWEM\E1AK3?$5E\$tJyM%%&%%$fifthfifi
`
`iiiHiH’éiT—fifififl‘L7”:fifi§fiifi‘fi%¥ilfiilfi4 O n mag/{y |~“/\°7\7 4 )l/QT‘WTEUDEPID
`
`

`

`WO 2013/031137
`
`6
`
`PCT/JP2012/005243
`
`SEES}: )Cfifi‘fi LA Elfllllxififirta) h V E G F @EEEEEE L730 %U>.%E
`
`E\ EPzDifx’EG O O n m7b\t‘oEP/l:\$)*x’E7 O O n mOJF'afi’Cx
`
`h V E G FUJFEE
`
`§b€EE§=EJE7QI< 732512;???)75‘9730
`
`[0024]
`
`Ek‘I1BKEEE5E‘EEK‘Et/vME%E%%$fiTEFE
`
`EEEKEELEEEEEEEE4Onmwmykmz74wafifiiwm
`
`[Dififiéttcfifi'fi LA EFIDSEEScEODEfl—Efifi/f bin/ryODFEEtl: (EEL,
`
`EVE-I: EEEc‘: bfcth) Etbfixw‘co %ODI’EE EPIU>§E6 5 O n m’C
`
`\ Efflifiir Ida/r waitbb§EE1fi< 72:5 (EEGIIJEUémé) :tb‘b
`
`b‘13ito
`
`[0025]
`
`@3\I1BTW\EE%EESELEWQEEE@Efififi4hb4/w
`
`EEEEEE(F1J)tLT\EE%®fiECt®EEfifi4FE4v®
`
`EEtbéEEE’JtfiE’C‘a—VL’CVEO E7”; I1 SEPT“); SEEK“: (Witzf
`
`450nm‘550nm@8)K~E#BTNFa‘lL—1B‘IFNy
`
`lL—6‘lL—12awflfi‘§EEHfi4FE4V®E$K®EEE
`
`a—VL’Cméo
`
`[0026]
`
`OEU\iEwEEfiB‘EmmfifiwfiEfiéEEKEEbefififi
`
`4FE4V®EEEWEEEZKE$U‘EEXEZXAwEEHEE®E
`
`Efiflfitméo
`
`[0027]
`
`UFK\E%E®EE®EM1kbU5fiEEEiEB$U%hEfizt%
`
`EEEE- EEEiEKDmT I2be4EEmTEEEé
`
`[@028]
`
`IzmxwawEwwéEufiéfiEEfiE- EWE EwflflEEIf
`
`@éoISMIEEmwéfikEéEEEEE $WfiiEmEWflEITE
`
`5 I4): HEE’EOD ’“WJEéfi‘fiE'EE/E‘JE EBJSEiEwfi‘fiEEwfiéfifiI’C
`
`55%50
`
`[0029]
`
`EEmwéEwfifiEfiE- EWKiE1tLT It EEEEEwEE
`
`EEBE L E 7”:IJITEEHEODEEODEEEESE?EEBESSEE EH éféfiifiEE’fD
`
`\EEHEEEEE¢5CtE$UEEHEE®EEEEH5EEEE(E
`
`E) atwlfiEémwétwt-Evéj‘uE€E iIEEWULCEEHEE
`
`

`

`WO 2013/031137
`
`7
`
`PCT/JP2012/005243
`
`[@030]
`
`ifxE2#BE4K%?$5E\$$fl®é§®fifi%fifi-¥M%E
`
`\
`1m\ya<ttM%%EM%?é%%fl2t\fi%fl3t\§%$4t\
`
`fiEEfiflBt‘fififlfl%6t‘Efifififl7t‘fifi$w8(E3%%
`
`)téfiiéofi%%3m‘%%%2#5M%$m§M%%EE%%4mfi
`
`HTE%?5°§%%4H‘E%%3TE%$ME§%%EEE$ETW%
`
`%WE§%?éofiEEfi$5m‘%%%2#5M%$m5M%%®56%
`
`Ewfifififl®M%%%Efiéfiéofififlfl$6fifififl2®fifiéflm
`
`L\fififififl7m%%fl23$0%%flflfl6mfifiéfifiiéo
`
`[0031]
`
`@B\%%flflfl6m\mFKfiifififia—yfi%%fl2w%%éflm
`
`iéoflifi\%%fl2&1Eitmfififimfififfi%%%éfiéo:0
`
`2:3 %i‘fifif$2Effifiifillfiltcfifi’cfifi‘fi%fi‘fiéfiéizE-fitcti‘ $66:%§‘fifif$2
`
`#M%¢6M%I*w¥—%WE®M%I*w¥—MFKW1Tfifififié
`
`fiftimoik‘fififiZEfiiwfififififififiéfiémfiwflmE?
`
`5°
`
`[0032]
`
`Ek\H2Efi?%fi#%%7fi‘%%%34t‘E%@%35t\%fi
`
`$36t\$fifi36®1v-17EWU§ié%fix4v%37t‘Efi
`
`Zéoma‘fifififi$7m‘fififlflfl6wfifitbfbmm5méo
`
`[0033]
`
`gfifl34fi\WZW%%%2E%%$fié®fl%%®%fifi§éfib\
`
`fifiQtfiwfififiéhéifly?y#fiafimém\%%fl2®%%1?
`
`wfi—égiéofififi%35m\Efifl36éfibffifiéméafiég
`
`E$34Efifitéoafi$36u\wiw757§H(%fiflytyh)
`
`mfifibfafiwfifiéfiwfiwétwwfa7t%fi#—7wt@fii\
`
`%%%34m%%&mfitéoma‘fififlsau‘fiwiEManma
`
`Efizffiflbftimo:mmiU‘%%%%E®%%fififiifiéo
`
`[0034]
`
`Ek‘H3Efi?%§$%8m‘%%%2‘E%fl3‘§%%4\fififi
`
`fifl5‘%%flfl%6aifififififi%7Emmiétttu‘fififififi
`
`5figfifi$mkfifi%(fl%fi)éfi%%®%MLkv%fiiEME%L
`
`:$fi(%ififi)fifi%flflflfifiéfibfv5o
`
`

`

`WO 2013/031137
`
`8
`
`PCT/JP2012/005243
`
`[@035]
`
`%LT\%E$W8M\QE<tE—D®%D&fi?éxflififififw
`
`%W(EE%%WE§U)Efifl$h\%%fl2\fi%fl3\§%%4\fi
`
`EEEflS‘fififlflfiG‘Efifififl7@8%W@?é7—Dyfiéfifl
`
`LTW\%O
`
`[0036]
`
`$BK\%E$W8H‘9m<ttfififl39t‘%E$W8E%BE&
`
`fcwtfiEfifi'éEfifiB4 Oc‘; Efifiiéo EEEE‘BS 961‘ 4§Uiti%®$LC%
`
`Efiflwfifiwfl%%%fi%¢ékwfi‘§E$¢8®—F®E(HT‘F
`
`IEEJ tfifi?%>)
`
`tCfiZfiESJI’Léfi-EIEIE‘B3 8b‘61fiflfi7‘3fiéfilL/TEEE?
`
`fi?%éo
`
`[0037]
`
`D§K\%E$w8nwméné%%fl2mav1\E4E%VTfi%?
`
`6°
`
`[@038]
`
`H4K%?¢5E\%%$2m\wm<tfififi9t\fi%fi10t\7
`
`p*wpy211t‘éfiiéo7bfiwpy211u‘fi%$1owfin
`
`$KWUHH6M‘fiEEfi$5EA%?%M%%®A%%EEE§?%O
`
`[0039]
`
`:wtfi\%%fl2m‘%fiA($fimwafiuamrm‘fifiv%é§
`
`fifl4®$1®§fifi12§fi§éfikfii®£fi)$Utfifi%%tfifi
`
`m(Emfim:m)E$H5m1méo
`
`[0040]
`
`ik\%%$2®%fi9fi\Wifi$t1DM%E%AD¢>M%%@E
`
`w(fi%)M%§@£T%m$n\$W®¥Mbkvflmikmfifibkfl
`
`fluxfifififi4hb4ywfiiémflfiéfiE®M%%éfi%fiéom5
`
`xfififlwéfififixfifi9fi$tJVM%%%%kaTfififiéo
`
`[@041]
`
`itx%%fl2®§%$1om\gfifl4wfi1wgfifi1znfitéfi
`
`fiAiUgfifl4®W%%WWt§WWEfififi‘Wiwm%%2aéfi%
`
`$3EEH§%%4EE%?éOEfiE‘E%$1OH‘EfiAE‘DEU
`
`§%%4®W%%WWKE#5‘flzfiM%%2b%E%%3ikm§%%
`
`4EE%?50
`
`[0042]
`
`ik\7b?»vy211fi\Wifififiéfi$5ml%fimfifiéfii
`
`574waéflv5%fimawgnéozwtfi\7b$wpy211m\
`
`

`

`WO 2013/031137
`
`9
`
`PCT/JP2012/005243
`
`fifi9#6A%$hél%fi§fififitéfi§fififl5@fififlfiml%fi
`
`ELXWtaéiitcéfiwl‘oméo 7333‘ WE‘EEE‘BM; WUthfkfin‘fiaflEfi
`
`fifimvéfiaz74wamaéflmé%é‘7b*wpy211&%%b
`
`’C’EJJHAO
`
`[0043]
`
`ti 7‘;
`
`Jifim‘fifl 3 can Sfix’EEiflfiB 5 Efiifi L7“:)55I§m‘fi'fi&¥f5)3 LEVEMEE 7°:
`
`Hfifibk%fi(%i%fi)Efi%?é$5m‘%fi9fig%fififi(fifi
`
`fiéfib)KM%$M5M%%®fi%fifléflfl¢éo
`
`[0044]
`
`%LT\$%W®%%®§%fl3M‘%%fl2#6M%$méM%%%§
`
`fi‘fifif540>%1 ODE—fi'fifi1 26:E%fi?é%1®§%fififi1 62; %fi‘fifif$27‘3‘l‘ofifil
`
`%$hém%%®—%E%2®§%fi19EE%?§%3®E%fl20t\
`
`%3 UDJifia‘E‘BZ O’C‘Jifia‘énétfilfia‘fi'fiéiéfi‘fififi4 03%1 UDiEfi‘fiE 1 2 tbiifii
`
`@5fi20fififi18KE%?%%2®E%fl19t\Efiiéo
`
`[0045]
`
`5:03:53?‘
`
`.46233141’)“; JifififiBS®$1ODJi§fifiB1 60; fifi‘fififm
`
`®%1®§%E12Efifibfmfifim1béo%LT‘E%%3®%1®
`
`Jififi‘m 6 tigffi‘fififm 0%1 ®i§%fi1 2 thafiBELi~ %fi‘fifif527b\l‘oi§< 7::
`
`étifiéfié<flé$5td¥35§éhéo 0&be fififimafliQfifiEEfiéfié
`
`{fifib“%fi‘fifif$27§\6i§< 22:50:21 $1 UDJifim‘fifH 6®Jifififiti§¥fifif$4®
`
`%1ODi~E—fi‘fifi1 2 tODFafiODfi‘fiE%E7b“%E< 72:54: 5 LEEflfifihéo EMSEI’JLCL:
`
`\ Zkfifi’tfiwfiéfiéfiti‘
`
`.4CCZTTj_<J:5L—_\ WUZLzfiJiEm‘fiBB 03%1 wlififl‘fiffl
`
`6b‘7k3FEELCEfiti6m‘ gfi‘fififm 03%1 @E—fi‘fifi1 2Li%fi‘fifif$21fiU7’J\l‘o%
`
`fi‘fifiBZUJJififlfiU (IEP’Gtzh man)
`
`t:rfij7b\a'CJi%fi‘r530>%1 @Jifim‘fiffl 6
`
`twflfififibfii< (59R) 7315$5621EE$4LT§§U51¢1U50 728‘ $10)
`
`E%%16m‘%%fl2®§%$10#6%fifi(fifiéfin)L1%m$
`
`Tl“ $1 @Ei‘fifi1 209%fi‘fifil32{flUtfifiifluwfinfifiBwfiEi’Gififi611’0»
`
`5°
`
`[0046]
`
`—F‘E%%3®%2®E%%19m‘fifi$4EEfl?é%1®§%fi
`
`123$6$2®§fifi18éahfi\%1®§%%16tfifibffifiw
`
`Liflflfiénfméo %L,”C\
`
`Jiém‘fifis 03%2091i3m‘fif51 QtiE—fi‘fififMODfiZ
`
`

`

`WO 2013/031137
`
`1O
`
`PCT/JPZOlZ/005243
`
`wEEE1sthEE EEWbeE <EéEt‘E<@é¢5EEE$
`
`EEOOEU EEW4®EEEEEE$ fiéfiE#%%W2fibE <aé
`
`Efi‘E2®EEE19®§EEtEEE4®E2®EEE18t®E®E
`
`EEEE<EE$5EEE$EEOEEEEE‘EEEmZETE‘E4E
`
`Eiian WKHEfiW4®$2®EfiE18fim$finflmfibh E
`
`EE3®E2®EEE19EEEE2WfiBEfiE2®EEE(METE‘
`
`Em)mEfioTwEEE4®E2wEEE19thEfiE<(E<)m
`
`6&5KEELTEEQHmeVE ab EEE3®E2®EEW19®E
`
`Em EEW4®E2®EEE18®LEEETEELTméfi‘meEb
`
`nmmztmm5iTEEvoiEEEE\EEEwfiEwfifiEEE*Efi
`
`EwEEEA®MEE®EEEEELTmé:tngétwfibéoDiv
`
`xEwEETEEEEE4hb4v®E$fiwmm®T\EwEAwEEE
`
`LQVEWKLEZtKJEB®TEEO
`
`[0047]
`
`EBK‘fiEES®E3®EEE20E\EEEZwfiEQEEEEfim
`
`EMEEEEEEEEEET WKEEEW4¢EEELE5t®EEEF
`
`L?é$5flfiE$hTV%o%LT\E3®EEEZOE\%%E2%E
`
`Eié7bfiwby211fi‘EEESEEH5MEEEEEE5EELT
`
`EELTEEEMEOOEU\E3®EEE20E\%%E2#6E1®E
`
`EE16nfifiafiEtEEEéEEUn3mT\EswfiEEzowEE
`
`EEE5E®EEEEEEE2KE#9T\EEEEE5EELT‘W1E
`
`4 5° @fifiEwEETEELTEEénéo
`
`[@048]
`
`HTK\ESQEEEZOQEWEEGWEEDUT\EBAtEBBE
`
`EbTEELCEEB‘éo
`
`[0049]
`
`ESAE‘EEEwEmwéEkEéfiEEfiE- EEEiEODE3®J§E
`
`EMEEEEI’GEEO .5 80th EEEO) é‘mLEéEEESE - EBHE
`
`EwEswfiEEmeEEEEEEfiEKEEHEEEO
`
`[0050]
`
`H5AtE5BEEE$5E\E3®EEE20H\%%E2#6MEE
`
`REMEEEE2®EEE1QKEEEEEEE26t\EEE2#6ME
`
`

`

`WO 2013/031137
`
`1 1
`
`PCT/JP2012/005243
`
`$héM%%®—fléfifi$fif%1wfi%fl16A®%%E%fltéfifi
`
`$27téfiiéo
`
`[0051]
`
`%LT‘$3®§%%20®$W%26m‘$E%fifififl$m\$Wfi
`
`260Efi$29figfifi4wfi1wgfifi12EEE$hfbéo—F‘
`
`$30E%%20®$W%26®%fi%30fi\KEEE%SETEE$M
`
`1‘fiEEfi$5®—$($%mwéfifiu‘fiEEfi$5w¥fififi>é
`
`E5$5EfifibfflfifihéoDiU‘%3®E%%®Efi%mfififi%
`
`mmfiflbffifiéméoCmK$U\$Wfl26H\%1®§%$16t
`
`%2®E%fi19tfifififl2fi%m%$mém%%éfimfiéo
`
`[0052]
`
`it\$30Kflflzowfifiw27m\$1wfififi12®%%fl2w
`
`nfibaw%%®%%ébN—téxwflz60%fiflsobamficwfi
`
`EELCEQHBTMSO zwtih fiiflfi527ti 2|:17l<fir$2 ecorlEHE-UD (I58
`
`mfifififififi)E‘Wifi—EEETE&%W$MéO
`
`[0053]
`
`fiam‘$3®§%%20@Efi%27m‘$W$26wfififlsomfi
`
`imlfilfimca'fifififififls owagfififififlz 9 urn-175w? WUKLizlsgéb'Ea) éiié’ccztz
`
`fififiEWURVTfifl$MéOC®t§\%3®&%%ZO®Efi%27
`
`M\%1®§%E12#Bfifiiéfi5‘OEU‘%%%2Kfifi<fiE%
`
`Dfifibfflfiiéifitfififil‘ohéo lmtciw EEEEZ 763‘ $109§
`
`fifi12figfifiiéfi8\DEU\%%fl2Efi3<fiE\%%$2#B
`
`M%$hém%%®%1®§%fl16A0Efifi§fi%m?éo
`
`[@054]
`
`itxfififl4mxfl4nfiiiimx%h%hfifibffifi$né%1
`
`®§%E1Zt\%2®fififi18t\Efiiéoaa\$%flwéfifim
`
`‘%1®§%E1ZH‘E%%®$®$($E#BE%ET®$®%W®E
`
`)Kfifibffififim%o—H‘$20§fifi18m‘fififiwiw$(%
`
`E#BE%E?®$®WWQE)EWELTEEfiMéO
`
`[0055]
`
`ik‘fiEEE$5E‘%%%2#BE%%3®%1®E%%16EEH
`
`1M%$méM%%®%%ifi\$$fi®%%fififi%%3w%3wfi%%
`
`20$UB%%$£WK\EE$mTVé°m3\WEEE$5H\%%%
`
`

`

`WO 2013/031137
`
`12
`
`PCT/JP2012/005243
`
`2#5@M%%®‘1m:w%$wfi§fifl\itm1miw%fiwfififi
`
`fl®M%%®&EEfi?é%$74w&?%fl$hfméo
`
`[m%] %ZT‘MFTM‘$$fl®3fi®fi§fififl5wfi$74w5tbf‘
`
`%E®fi§fifl(fi§%)®M%%®&EEfiWEEE?éflyKNX74
`
`w?(¥%74»9)EWE\fiEEfi%5®W%-W%E9mf\ESE
`
`Ffiv’cfifififia‘éo
`
`[0057]
`
`ammo; ififi‘éiflfim can
`
`ifiEifiB 6 6.
`
`5 n mL;U:7 8 o n mm?
`
`wfiflW®M%%%EfiéfiémyKN274»&T%%O
`
`[%%] E6M\$%%®$fl®3%K%é%fi%$fi-¥M%Euflvtflyk
`
`N174wa(fififififl)®M%%®fi%%fiéfi?fi57wflfifiéo
`
`LLL‘F’C‘Wah $¥E$C~Ed>fi¥fi¢$fiéfitél§y |<‘/<’7\7 «r ”/9721“? |<‘/<’7\
`
`74JI/SIC~E<‘:%TL%“TL$7I\©‘%>O 7238‘
`
`l6d>3§ffkfiAti 3%?74Jb’975:
`
`Efifififvmvfi%®M%%mfifi%fi&fiLfvéo
`
`[00591l6tzzfi3‘iita i3? én‘y R/i’2741b5'78i3‘iiflbfcfifia‘fi‘fiwfifi‘fi
`
`%fi(fi%fifi$)®fi§fifl®$fifim\ificvfiimbfifiaoon
`
`mwmykmx74wacwfifi$fififitméfifi(fifiC:®bénfi
`
`miéifx’ES 6 6.
`
`5 n m) ®Efi$®2fi®1 ($6?) ttfiéfiifx’fima)
`
`fiE(%fiCi®afiflfim?éfiE)T%éo—F\§N>KNX74w
`
`aéfifibkm%%wfi%%fi(fifififi$)wfifififlwimfim\Em
`
`fiwfiififi78onmfi%éo
`
`[WW] DiU\m%%®¢flfifi600nméfifiéNDKNX74w9Cfix
`
`E1AufitianhVEGFQEEEEWfl¢é@§#%éfiE%EE¢
`
`éfi$74w9fikéoma‘NyHRX74w90$UEWEW®‘E6
`
`0%?fi7fiB’Ga—xa‘EP/LWE5 2 5 n m®fi%¢%'r$%E?é/<> |<‘/\°7\7 41M!
`
`BH\E1A®%%#6‘hVEGF®E$§EWfl¢éW$fifiVt%Z
`
`aha, choc; U‘ Ell/DWX’EE; o o n mUDN) |<‘/\°7\7 4 )bacwfiiflifi
`
`mmaéwfififi\fififififbh47éflfl?é@§fi%é?flfifi%é
`
`tflmfifiéo
`
`

`

`WO 2013/031137
`
`13
`
`PCT/JP20 12/005243
`
`[@061]
`
`—E\E6mfitfififlfi(fifi780nmfl)®M%%m\fiflfinfi
`
`%?éfifi%fl@%§fiifim®fi\fififlfii?®flfi%(fi§780n
`
`mm?)ifiwfifififlé‘fiEEfiflBfiEfiéfiéififithméo
`
`[0062]
`
`72:35“
`
`ifiE‘fiiiflfiM t chcat‘
`
`5 6 6.
`
`5 n mLLLJ17 4 6 n mLLL‘FOJSRjE
`
`fiflW®M%%EEfififié%$74w9fifiiLboOEU\fifififlw
`
`ififi(746nmfl?)fi‘H6®$fiETfii¢flfiE700nm®fi
`
`%%HEE?5NVFNZ74w9E®Efi$fififitméfiE($fiEi
`
`wdfimfimfiéfifi676.5nm)®fifi$®2fiw1($fi)t@é
`
`EWEW®WE($fiEwa$Efim?6fiE)Tfiéo
`
`[0063]
`
`DiU\M%%®¢@WE700nméfi?éN7KNX74w5Efi\
`
`E1AnfifiiinhVEGFQEEEEWfltéflfififiéfififififi?
`
`éfi$74w&?%50@5\NyRNX74ng$UEWEfl®\E6
`
`®%fiFfifitmflfiE88onm@fi%%fiéfitémykmz74wa
`
`FH‘H1A®E%#B‘hVEGF®E$§éWfl¢§W$fifiVt%Z
`
`61150 ZTLLCA: LL FPIDSBZE7 o o n many |<‘/\°7\7 41M» EODESBZE
`
`mwféwfififi\fifififi4ht4v€flfl¢5®§fifiéET%étfl
`
`mfifiéo
`
`[0064]
`
`—H\NDKNX74w5E®LRET%éWE78Onm($fiEiw
`
`gfinfimiéfifi)t\$3fi§880nmwmykfiz74waFéE
`
`E?6M%%®fiEJUEfifiEWTEéO%®kw\fiE78Onm®M
`
`%%E%%?éztngéfifififi4hb4y®mfl%%éfifitétwfi
`
`m@<\mfl%%(W%)®@§#%éEtflfififiéo
`
`[0065]
`
`figfi‘fiEEfifl5tLTM‘fiEfiGOOanL700anT®
`
`WEfiEW®M%%EEE$fi%%$74w9fi‘$UHELDO
`
`[0066]
`
`OEU‘H1AEfifii5E~hVEGFwfiiiémfliéltfifi§
`
`65$E®fii§fi¥fi§i§ifl¢éfi$7 4 )lx’9'63355PID3R1E6 O O n m (ifffiC
`
`Lwcémfimfiéfifi)éfiiémykfiz74wac\Biwmbfifi
`
`700nm(£fiEiwegnfimiéfiE)@fitémykmz74»&
`
`

`

`WO 2013/031137
`
`14
`
`PCT/JP2012/005243
`
`Eéx 4§Uiti§fifl€>ébfiffifib\éo
`
`11167.4:be firetcfiéfififi’r Ida/{‘2
`
`wfiiéamflfifimflfifiéo
`
`[mm]
`
`ik‘E1Bmfifiififi‘fifififi4hb4ywfiiwmflfl%®%é
`
`‘
`
`GwiffifiD’Gzfia‘EPIDiR/ZEG 5 o n mwfifi‘fifliéfia‘éxw B‘/\°7\7
`
`4»? D Efiifla‘éfiifia‘fi‘twififififilm Ell/DSJEEG O O n m0)/\“/ |<‘/\°X
`
`7 4 )I/SI Ct‘ EPaniflx’E7 o o n mwn‘y HAD—<7 4 )I/9 EOJF'EfiLUEEL'C
`
`méo Oi LL A‘y I<‘/\°7\7 «HI/90 tn‘y I<‘/<’7\7 4»? Ewififififilb“
`
`\ Ell/Difx’Ecs 5 o n m®fifififi¢§¢$éfi¢él<y I<‘/\°:<7 4 )I/sl DUJSFiEfifiI
`
`tifltéo %OD7‘:&)\ EPIE\3RZE6 O O n mOD/K‘y |\“/\°7\7 4 )I/S’C (‘2‘ EPID
`
`WE700nmwNyFNZ74w5EEEE?6fiE®M%%E\fififi
`
`#4 |\jJ/ry®E$E$ID$U?é§W%7b§hét%i451160
`
`[mw] HFK\$%%®$fl®%%uawéfifi%%fi-%M%E1wflWED
`
`m1~§wmfififiiéo
`
`[ww]
`
`if‘ESEfifigfi$W8mfiflfl38wg‘fiflfimfifi%WT%é
`
`\ {§Uzti$7&fil?éo ZUDti?‘ {Efiifiwidfifitfi‘itmé‘ DEUI4
`
`mi?%1w§%fi12flu¥®$E\%2®§%fi18mu%®$fififi
`
`iéifitc‘ £E$W8P~Jta fififi'fitiiafiliéo max #fifififia‘fimfifl
`
`4%ch ifiafiflfitcflfliéhétw‘éfitfifl iwfiabffizwgfi‘fifi1 81E|JL
`
`idfilib‘fi 1 wigfi'fifi 1 21fiUt$€irfiU§Lé$ 5 t; iwfigéififit: bffilt:
`
`L’Cibctmzcttztmfii’éibttmo
`
`[mm] DfinxfiE$W8KW%%MTbéififilbkfi%T\fiE$W8®
`
`ifiz4v%(flfifif)&jymfiéoanniu\%%%fifi-%M%
`
`E1mfififiku‘fififlflfl6ufififl2wfifi9E%%$ETM%%E
`
`M%$fiéo
`
`[mm] %LT\H4ufi?%%$2®%fi9fi6fl%fihkm%%m‘EE%5
`
`mm&%$10?fi%$m1%%mn7vzwvy211EfifioTM%é
`
`1150
`
`[mm]
`
`:®t$\7biwuy211nfifibtm%%®55\7vi»py2
`
`

`

`WO 2013/031137
`
`15
`
`PCT/JPZOlZ/005243
`
`11&Efibsfififl4wfi1wfififi12itm%1@§%fl16nfi#
`
`DTM%$%5M%%®—$\Wifim%fi2bfi\$1®§%E1Z%E
`
`fibf‘fi%%®$®$fifi%$méo
`
`[0073]
`
`—H‘%%%2#5M%$mt%1®§%fi12Efifi5mflwfiU®M
`
`%%®\Wififl%%2a®—%®M%%15am‘$3®E%fl200$
`
`Wfl26fifi%$m1‘l%%tLT‘%2®E%%19E§#m5O%L
`
`t\%2®§%fl1gmgwth%%15am\%2®§%%19TE%
`
`$MT\%2w§%E18#B@%%@$®$E%%$héo
`
`[0074]
`
`L#L\fifixfifi$4®%1wgfifi12nk%?ém%%fi\$3®
`
`EEfiflZZ O ccirgamétn %fi'fifif$24fiud>fi‘fi%7b‘w7§: < awarmmao %
`
`:T\$$fl®2fififi\%%fl2flfififlbfmfiéhé%3®fi%fi2
`
`OODZMZFEI‘BZ 6 wfi'fifififififis OfiUtc‘fiiflfiBZ 7 EEQHZQO :nLCJ: LL $3 (D
`
`E%%2OKE#5M%%2a®—%®M%%15bfi~%3®§%%20
`
`®Efi%27éfifibf‘$1®§%E12®%%$2wwfifiéfi%i5
`
`o%®fi%‘fififl4®$1®§fifi12wfifi$2fl®fi§€fimfifié
`
`:t#?$éo
`
`[0075]
`
`ik‘H5AK$¢$5K‘fififlzmmfifiLTmE$M5%3®E%
`
`flzowfififiz7m\%%%2Efifi<$W$26w%fifisoWfiafi
`
`DEE#Mi?5%fi?%mémtv50%wkw\§%%4®%1w§%
`
`E12®%%fl2figfihkflfi(fiflbt\fifiQfiawfifififiE<m
`
`éflfi)Afiflhém%%fi8%<fififl27éfifitéo%®fi%\§%
`
`fl4wfi1wgfifi1znawéfifififiwfi—mfiflméo
`
`[0076]
`
`LLL‘FLC‘
`
`iEEEEBZEE—fiéfis @Jifin‘fiBZ CONFFH - flfitzom’c‘ E171:
`
`WE‘E7Aflgfl8BéflmTfifi?éo
`
`[0077]
`
`7 A can 213%Efiwififiwfiéffilgwifi’fifiu tc1fi7¢é¥tfifififi$fiflp§ - $Bfi§§fi®¥§
`
`fi%fi®%1®§%E#B%%SMEM%%®Wfi%EKBH5fiEfi$E
`
`?%50E7Bm\fi$m®éfiw$flmm%éfifi%%fi-%M%Ewfi
`
`fi%fi®%2®§%fi#6%%$nkm%%wmfi%fiuawéfififififl
`
`

`

`WO 2013/031137
`
`16
`
`PCT/JPZOlZ/005243
`
`’C‘Woéo I8 Aczt‘ Eli/3E0) éfi‘émtbfia‘afifltchfiéfi‘fififiafifififlrfi - $Bfiéfifiw¥§
`
`%%E®%1®§%E#B%%$ntm%%®mfi%fimawéfififififl
`
`T3350 I8 Bosh EIE‘EE’EUJ éfiwttfis‘afiUtd/Sfiéfi‘fifififififififi - $Bfié€f§®¥§
`
`fififififim$ 2 @E—fi‘fifiifi afififim‘fi mkfifififiwfffifififia‘fit: $361 éfififififi‘fil
`
`Tfiéo
`
`[0078]
`
`@B‘E7AH‘$1®§fifi12b6$®$flflfi%$htm%%ww
`
`fi%fifi3fiéfi§fififlfi‘E7BM‘%2®§%E18#6¥®$WE
`
`fifififl‘é mfcfifilfia‘fi‘fiwmfififia‘fitcaHéfififéfifi‘filézfi L‘C v50 1 r. ‘6
`
`7 A 2:I 7 B t:a‘<3‘fifif§fi¥filtzL IEIJODEfifififiE—fi'fifiM wfifi‘fififi 21flua>fififi
`
`flwfifififimfiéo%LT\H7Atfl7B®EWfi6EWEfiflfififi
`
`7b“ I3ccfxtfilfi$w8wfififiaEfi4fiu (Efilflfifis 81EEJJ)
`
`tcrfiubfifirfifl
`
`czfififia‘éo
`
`[0079]
`
`ik~E7AtE7BE%?%1®§%E12®%%%2wwfiflWT~
`
`fiffifiE’GZTVQWEELL —fixES7E1EH%%OD$E§Eb<Eb\1/LGtf§$ bfdfifi (5E
`
`%%4@%%%2W®fi%#5%20mm%MEmE)uwmbrméo—
`
`73‘
`
`fi$§FTZT<$1fiELaK —fi:E’9tMEJ%%0>$EODHH$EOMfiE (Efi‘tfimw
`
`fifi‘fififs 2 {EUOJfififiE‘Bb‘Bfi 1 O O m m'fiii'fiil’tfdfifi)
`
`07.30155 L’CL\%)O
`
`[0080]
`
`:5 Pot; .7 AtI7 BODIEPLCZEELTT’EFaa‘ b\ 0‘ d\ e\
`
`1“ 9‘
`
`h\i\j\km‘W%%fifimiémkmiwfigwfifi(fifi)Efib
`
`TvéOEWWKfi\HEaH6OOIxMi®fiEEE¢fiWT\H%b
`
`#6H%kifimaooIxfig50Ixfifi?®%E®%H&fifinfib
`
`zméo
`
`[0081]
`
`—E‘E8AtE8BH‘E7AtE7BEfi?$$%®%%®Efifi2
`
`7&E?é%3®fi%$2owfifififitmfifiékmmflfifltLT‘E
`
`E3552 7 am}? L72:u%3 wfifijfifl
`
`(2M$%BOJJ}’C‘$§E‘Z) Efifimfcc‘: 309$)?
`
`fifia‘fitcaacjéfififififi‘EIEzT-xL’CL\%>° 72:25“ %mm&+wfifli%fi%tga
`
`can Elbfiigé®TEFEEHE§E§§LéO
`
`[0082]
`
`%LT\$1®§fifi12#6%%$htm%%®fifi%fifiafiéfig
`
`

`

`WO 2013/031137
`
`17
`
`PCT/JP20 12/005243
`
`fi‘FEEa—V3'I 7 A ®$5E4§U t
`
`8 A @Ltfifl t Zittfij'é tx $3fi1§fltitb$§
`
`WEENT\fifififiwflm#%%fifi%U\fifififi—Efifibfmé:
`
`tbfibfféo
`
`[0083]
`
`filfifl;
`
`5% 2 @Efi‘fifi 1 8 75‘ "ofififim‘fi mrcmmwmaaficcawwar;
`
`fifi‘fiézfia‘l 7 B @ifi’fifiu c‘:
`
`8 B wtbfiafiu c‘: Ettis‘aa‘é c‘; $EE1§ULsttb$§
`
`WEENT‘fi§fi$®@m#%%#F%U‘fifififi—Efifibfmé:
`
`tifl’flb‘éo
`
`[0084]
`
`DiU\$3®E%$20EEE%27€%H6C&K$U\W%%EE
`
`awéfiafifiéfi—Kfifiéztfibbéo
`
`[0085]
`
`mFK\E7AtE8A3$0E7BtE8B®%flWtEfiWE3H6
`
`\%Efi$@%§&\EQAtEQBéfimffiflufiwtéo
`
`[@086]
`
`9 A can
`
`7 A mam t
`
`8 A 0>tt$§1§Utc4n€é¥fififififi$m§- $Bfiéfifi
`
`@fififififlmamf~%1®§%E#6%%$MEM%%®W%%E®E
`
`Etfifit®%%Efi?757mflfi%%oEQBH‘H7B®¥fifltfl
`
`8B®mfimu%é%fi%%fi-$M§E®fi§fififluamf\%2®§
`
`fififi6fi%$mtm%%®W%%fi®fiEtfiEt®%%E%?757®
`
`HT$§°@B‘H9Atfl98®EHH\E7AtE8AB$0E7Bt
`
`E8B®§fiefififififinfimbrv5o
`
`[0087]
`
`CCT\EQAtEQBwfifiXM\E7AtE7BKfi?$%W®%%
`
`wfiwflwfififi$®?—5T\mfiYM\E7AtE7BKfifikfiW®
`
`fififi$®¥—&T%éo
`
`[@088]
`
`%LT\E9Atfl98®$fiXtmfiYt%mfitét\iflflmmfi
`
`WKENT‘fiEfiE®W%%E®%fiEE3H5flmfififififi%U~fl
`
`fifiw—[fimbrvétfimT350
`
`[0089]
`
`wifififibkiim\$%mwéfiuimm\$3®§%%20KEE
`
`$27%EHéZtE$U‘W%%EEBU5fiEfiE#E—mfifi%%fi
`
`B$fi%méfizk%fi%%%-$M§Eé$fififiéo
`/ JAE-
`33:13 mama?“ igfi‘fififi4ti $1®i§¥fifi12tfi2®i§
`
`if; $935450)
`
`[0090]
`
`

`

`WO 2013/031137
`
`18
`
`PCT/JP20 12/005243
`
`EE18figfléEE®EEEEELTVEOEbfxEEE®%hEn®
`
`EEEK\EEEZEBMEénéMEfiw—EEEsmfiEEZOTEE
`
`L’CEEE’MCEZODEEEM 9LC EEELCC JEETEBBODE1ODJ§EE1 635‘
`
`$0E2®EEE19®VEm#TMEEEEE$fié:tE$U~En?
`
`meEEKNEEEEEE4QEEQEEEEBEEEWEEETEEO
`
`EwEE‘1D®EEE2T‘EEwEEEEMEEEMELT‘WEEE
`
`mawEEEEEEEEEWEEEKEEEé:tfififiéo
`
`[0091]
`
`ab EEEwfiEEEE- EEEEEH LEEEEw EEEEEémé
`
`Ewfimm<‘EEEwEEEEELEvEEWEEmT\EQEETEE
`
`Cttimfii’cfittvc,
`
`[0092]
`
`WEE iEEEwEZEEL EHEEEEEE- EEEEE1E MEEE
`
`EEEEEEETEELE#\:nEEEéhétwfimamofliE\E
`
`Efifi4ht4waiwflfléEELtmeEWwEEEEHEELt
`
`EwifimEEKEEEéiimbftgboEELEW®EEtLT‘W
`
`EEEEE‘E‘EEEE‘EQEEEEEKEELTEEVOE6K\A
`
`EKEEEEEénmgmf‘AEmflwEEEEQEW®EEEEEEL
`
`EwEwEMEEEEELTEEvOLwEu‘EEEw 3EEBU6
`
`EEE>EE- EWEEE1®EEKEE$hE EE\EEE5EW®EEE
`
`ENE LEEEKEETEéCtHv5ETEEmO
`
`[0093]
`
`EE\EEE®EE®EEESEE- EWE*E1TE\MEEEEEEEE
`
`EEEE4LE4waEmeLEmEEmEEEEmEELEEEmE
`
`fiEEEEéEEEEEEEWEEELEE :nEEBhEUOEEEEE
`
`‘ WUZLE—EE’JtfiEEE EEUDEE’PEEEEEUDEEEEEUDEEE STE
`
`EE427b4QE®Nv054hflEwEfim—EEEEEEHEEER
`
`EEEEWLCWLTEEA:<i’:j—LCEEEéuZ\E #EéffiEEEEE\ ELCE
`
`EEEiEtLTEVTEEUOZMEE ULEEEEBEESMEMEEE
`
`EEEEEWLTE—KEEEéCtETEEO
`
`[0094]
`
`EkxEEEwfiEwEEESEE- EWE*E1TE EEwEEEIwM
`
`

`

`WO 2013/031137
`
`19
`
`PCT/JP20 12/005243
`
`%%&Efi$fiéfififififl5éfiitflfififiLtflxZhnmghmm
`
`°WZ@\fififi§fittffifi%%fiéflmé%éfim\fififififl5é
`
`fiwm<ftimoit‘fi%?éfifi%fimébfiffiméfifi(fififi
`
`)0M%%EEE?5WEEE%5E%KTE$VO
`
`[0095]
`
`if; $33550) affiffiwfi‘tfififia‘fififlxfi
`
`- $Bfié€fi1 ’6ch SFx’EEiEfiBS 9: LT
`
`KyHNX74waéfimkWTmfibkfi‘:mnmgmmmomzfi‘
`
`>3—bN274wfi(Efifimvh74w&)tnyfifiz74w&(fi
`
`fifitvh74wfi)téfiaébfif\l%$hkl%%w%fififlwfi
`
`E§Efibffifiéfiéfififififl5EfivtEivo
`
`[0096]
`
`if; fisaéfi’fiwfiii‘éwfi‘fififiawfifi - $Bfi§§f§1 (“can %fi‘l’:fif$2 wfi‘fiifi9 t
`
`L’CF'HfiHflfiWfifi‘étfi-EEE 1 zkbéw: 2 2|:FH MEWU’GEFEE'H L/7E7D‘K an
`
`Efighamoflifi\fifim\flfifimfiflflmfl$ht2$miwfifi
`
`Mgfii Tcti Efillfitififlfl LT:¥E§5£03 L E D ’6‘?) :9 ’C E A: LN,
`
`i7”; igyfififi
`
`mfififimflfimfim?%%fiéfivftivo
`
`[0097]
`
`if; 2!:331550) afiwa‘taaavsafig - $Bfié€f§1 ’6ch Ea‘tfim Eiéfi‘tfiifi
`
`lllfififlfi’é‘fiém’éififlfi Llfcb‘l ZTLLCBEBTLRVO {alibi fifi'fififflwfifi‘fi
`
`East Eafififil‘uj (Ea‘tfim wfi'afifimuwfifimma fifi‘fifififlfifltcrfiflb‘fififfifl
`
`) Kid Linaéfivfcflmfiflfif‘t ck < \
`
`filéFflfiéflfiTt ck V0 :wia-fi‘
`
`fi—ifi‘fifimzt‘ Efififiwi§=¥67fi®§é§£fimfiumfififimcfi?mfifick U *fifififia‘WfiM:
`
`fiflfi‘éhé Z: tb‘ihzi L,L\o
`
`[@098]
`
`if; iséEEEOD Zii‘éwi‘tfifiafislaflrfi - $BJS§§E1 ’Cvcztx
`
`fifi‘tfifm 09%1 091%
`
`fi‘fifi 1 2 acto‘fi 2 (Digfi‘tfi 1 8 iffifxfifil'fi’ifi L7Z£L\1§U’C°EFEEH waif: an
`
`HEM/Lame With Efififlmgfi'fifit; Hzfific'riéfiiéfizfifiz/deéfl
`
`L\’C =6 A: we
`
`[0099]
`
`ik\$%flwéfiwfifi%fifi-%E%E1TH\19®%%%2Kfi
`
`LT§%%4®%1®§%E123$U$2®§fifi18®29?%5%@
`
`Emmfiwbt#\:mmmammvomzw\1o®fifi$2mwur\
`
`3 DLXI®§¥6EEE¢6$§HZTB ct L», :m: ck U \ Wiczfiwfigm t“
`
`

`

`WO 2013/031137
`
`20
`
`PCT/JP20 12/005243
`
`®2EEH?@<‘$6E$®WEE8E£®EE€¢§W%%%E\1D
`
`@%%fl#6fl%$héfl%%é\fifim%%téztfififiéo%®%%
`
`‘fififi?fifi%fimm%%EM%T§ééfl$mfifi%%fiaifl%mé
`
`fiit%%%fifi-%W%E1E%fififiéo
`
`[0100]
`
`if; zliifi’fiwififiéwfi‘tfififidfififlifi - $Bfiéfifi1 («can EEEEZ 7 c‘: L?
`
`%3®E%%ZO®$W%26®%fi%30#6§fi%29fl[fifi915
`
`fifififlflUWfithflEflKfifibkfi‘:mmmgmmvo
`
`[0101]
`
`mint; Efififit Lt LX‘FLQ .1OAc‘2I1O BEJ3§VTEFEEH§L5$§
`
`)fifitium
`
`[0102]
`
`1 0 Mi ZIS%EHOD3EEEOD Zfi‘itdfifiéfi'fifififififififi - $BE§EEUDBUUDWU®
`
`$3®E%$Efi?EEET%éOE1OBM\E$E®Z%E%éfifi%
`
`fig-$M§E®$Bu%®fl®%30fi%fl%fitEfiflfi%éo
`
`[0103]
`
`OiU~H1OAK$¢$5K~%3®§%%42®Efifl43m‘$w
`
`$26®%fi%sowfififlfimfififi30wagfi%29mfi#af‘W
`
`zm¥fifififiitm¥flfifiumwRmffimbft$mothfi‘fi
`
`3®E%%42®Efi%4sfl\$1®§fifi12fi5fifiiéfi8\9i
`
`U\fifi$2mfifi<fiafiflfififififiié$5mfiwéo
`
`[0104]
`
`ik\H1OBE%?$5E\%3@§%%44®Efi%45fi\fififi
`
`DtfifiiéaéfifiHnmiwfiwfifiéfiiéfifiwzuvhfifimb
`
`T$$Uo:®t§\fifi$45TEéZUwhfi\$3®§%fl44®$
`
`wflz6@EEfiDm—fifiafifiufifiaffifibffimfihéo%Lf
`
`xfiwflzewfififlSOwszvh®EH\$Wfl26®§fi$29w
`
`szvhwfiwffifi<mé$5K%fl$Méo@3‘XUvbfiSOm
`
`L®%fi‘$W%26®%fi%30m#6~Efi$29flmfifioTXUv
`
`hwfifi‘flmfi<méiifififlfiéztfifiibmo
`
`[0105]
`
`CMBE$U‘%%%2#BM%SM5M%%®%1®E%%1BAQE
`
`fifiiéfifléfiéltfififiéo35E\§%%4®%1®§%fi12®
`
`%%%2w®%%%%m3fiéztfififiéo
`
`

`

`WO 2013/031137
`
`21
`
`PCT/JP2012/005243
`
`[@106]
`
`itx$$fl®éfi®fifi%%fi-¥M%E1TM\%1@§%fi125
`
`$0$2®§fifi18b6fié§fifl4EEE?5M%%®EE%EKDm
`
`TM‘Ewmfififibmfiokfi‘Wififififi4A®l%%E$Uw$m
`
`fififififiiégam‘wwm7U2A&%mLftivoiwmmm‘%
`
`1w§fifi125$G$2®§fifi18®fifi%%fltfififl®fi(Wfi%
`
`Wtfibfvmvfi)n‘A%%E$Umémfififififiiégauwmm
`
`7UXAégfififliéoCMK$U\§%%4#B%%$M5M%%#‘
`
`W%%WEE—Kfi%éméttn\%%%%Ewflwufifiamvifin
`
`fifififi?é I: c‘:7’3“'6§%>o
`
`[0107]
`
`mififibtiam\$%%®%fi%%EH\M%%EM%?6%%$t
`
`\M%%Efi%?éfiflflt\fi%fi#6fi%$htfl%%éfifi%fih§
`
`fitéfififlt\Efiiéo%Lf\§%flm%1wfififit%zwgfifi
`
`téEL~fi%%m%1®§%EKM%%®—fiéfi%fié%1wfi%%t
`
`‘%2®§%EKA%%E§%36%2®§%%t‘%2®E%%EM%%
`
`053% U UD—E‘BEAfifl‘fi‘fic‘: L’CEEfiB‘éEEfiBEEQLjfczk1flififib\ F9 725% 3 0)
`
`Jifia‘fiBc‘: Efia‘éo '5 B L; % 3 wEfififiBLiEfiE‘B1EUb‘fifi‘fifiB4flu tdbfifi L’C
`
`EEEL‘K M5 c‘: t 15 LC‘ % 3 ODEEfiBODSEiEEBLJ%fi‘fi%MCiED° < Li c‘i‘fifilfiflfi‘fia)
`
`EEfiEfi%M¢éfifléfiiTVéo
`
`[0108]
`
`:wfimnimfi\%%$#6M%$htm%%w—fim\Efi$évfi
`
`$3®§%%®Efifléfifibffi1®§%%Tfi%\hémmfifi\%1
`
`wfififimk%?éo%®&xfi%éhtm%fifi\%1®§%EEA%L
`
`1‘$1@fififiEEfiLTWfi%%®—E®flflfi%finéoit\%%
`
`fl#6M%$mEM%%®%U®—flfi‘%3®§%%T§%$m‘%2®
`
`Efifififl’éfifim‘é 116° %®¥§‘ EQBL'S mfcfifilfim‘fi‘fitst‘ % 2 ®i§%fil€l%if L
`
`T‘$20§fifiEEfibTWfi%W®fifiww(fififl)K%%$Méo
`
`9EU‘$%%®%fi%%EM‘—9®%%%ENLT‘E&®§%EEfi
`
`amuse
`
`[0109]
`
`is '5 t; % 3 (Dlififl‘fimah Eiflfifiéifib‘ 7:2|:1$%B7b\ BEER: Tu Eiflfiffifiu
`
`

`

`WO 2013/031137
`
`22
`
`PCT/JP2012/005243
`
`#EEEWEEELTEEEhTUEOZhK$U\%%E#BME$ht
`
`MEEH\E1®EEEEE2®EEEtEEEEfiE$hé°EE\E3
`
`wfiEEmEEEm‘EEEEE6<EEMEE®EEEEEEME5$5
`
`EEEfimfméoCREEU‘E1®EEEEEHEEEQEEE—EE
`
`EEEZtfififiéo
`
`WHM
`
`it EEEwEEEEEEM EswfiEEfi EEEEQEEETEE
`
`Smfméo:wEEKEME‘E3®EEEEEEEEEKEEEOin
`
`KANE EVEEEUEZIX HBEEEET‘EEO
`
`[0111]
`
`E7”; EEEUDEEEE‘azilEtat EEEEB7b‘l EEEBEIJLCED‘KLEEEEEIEE
`
`#EEEEEUWETEEEEEO
`
`[0112]
`
`E7”; EEEUDEEEEiEast EEEEB75‘K EEEBTEIJLCEEUEEEEEEIEE
`
`NIKEEEX U ‘y VGTEEEETLEO
`
`[0113]
`