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`t4974181 ~ GAL}: 1649
`Receipt date: 09/1 t/2014
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`Application Number I 14/374,181
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`Filing Date l2014-07—23
`First Named Inventor
`ITakaomi FUKUHARA
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`
`Takami, 8.: ”Recent progress in cell biological studies of human nasal chemosensory receptor cells“, The Japanese
`journal of taste and smell research, 1998, vol.5, no.2, pp.97-108, with partial English translation.
`
` 1
`
`2
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`Kameshima, N., et al.: "Correlation of AB deposition in the nasal cavity with the formation of senile plaques in the brain D
`of a transgenic mouse model of Alzheimer's disease", Neuroscience Letters, 2012, ppteeeee l6 6 — 16 9
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`Schenk, D., et al.: "immunization with amyloid—B attenuates Alzheimer—disease—like pathology in the PDAPP mouse",
`Letters to Nature, Vol. 400, July 8, 1999, pp.173-177.
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`E]
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`Hardy, J, et al.: "The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to
`Therapeutics", Science's Compass, Vol. 297, July 19, 2002, pp.353—356.
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`:]
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`Akatsu, H., et al.: "Hito Hana Nenmaku.Shukyu ni Okeru AB Kaiseki to Shindan no Kanosei", Dement Jpn, 15 October
`2012 (15.10.2012), Vol.26, no.4, page 509, with partial English translation.
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`6
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`International Search Report issued in PCT/’JP2013/000311, dated April 23, 2013, with English translation.
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`Date Considered
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