`Reply to Office Action of August 24, 2016
`
`Docket No: 069804—0374
`
`APPENDIX
`
`Listing of Claims:
`
`1. (Original) A method for immobilizing an antibody on a self-assembled monolayer, the
`method comprising steps of:
`a step (a) of preparing a substrate comprising one molecule of an amino acid and the self-
`assembled monolayer, wherein
`the one molecule of the amino acid is bound to the selfiassembled monolayer through a
`peptide bond represented by the following chemical formula (I):
`
`Self‘Assembed monolayef
`
`One molecule of amino acid
`
`/—’—A__\ K—_—"/\"'—‘\
`——————C—-N—CH-—c——0H
`
`llll
`
`0
`
`H
`
`R
`
`ll
`
`o
`
`---<1)
`
`(R represents side chain of one molecule of the amino acid)
`the one molecule of the amino acid is selected from the twenty kinds of amino acids
`consisting of cysteine, lysine, histidine, phenylalanine, tyrosine, glycine, asparagine, methionine,
`serine, tryptophan, leucine, glutamine, alanine, isoleucine, threonine, proline, glutamic acid, aspartic
`acid, argnine, and valine, and
`a step (b) of supplying the antibody to the substrate to form a peptide bond represented by
`the following chemical formula (II) as a result of reaction between the carboxyl group of the one
`molecule of the amino acid and the amino group of the antibody:
`
`self-assembled
`monolayer
`
`residue of one molecule
`of the amino acid
`
`peptide bond
`
`WW—L‘fi “--—----C——- N —— CH -- (3
`
`ll
`O
`
`l
`H
`
`L—Y—‘J
`
`|
`R
`
`peptide bond
`
`antibody
`
`DMuUS 77870385—10698040374
`
`7
`
`
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