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`
`
`
`ME 27% m WA
`(43) Date of A Puhiicea‘cion 21.99.3934
`
`"A Appiicatian Na 83953753
`
`(22) Date of Fifing mmasaa
`
`
`"13 ..: Appiicantiss}
`MEIR Lfimitad
`
`(513 ENT :15
`Am ma . 325.5 21132;
`
`€52)
`
`UK CE. {Editifln M}
`AER RET
`
`Name
`
`€58) Dacumams Cited
`
`1
`
`(585
`
`Fieid a!“ Seamh
`UK CL {Editisn L ; A58 REY, m2, 365‘ MP
`mm CL5 mam, mm , 325.3 ,GW
`gamma magma: WP:
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`(74} Agent and/0r Addmas é‘cr Sawica
`Mawbwn 55%;
`“(ark Heme, 23 Kingsway, LGNMBN, WW3 6H2
`Unitas Kingdsm
`
`fiacsrparated in the United Kisagdam)
`
`Waiwmh 3636: MDGVER Ham SW3 5%
`United Magda”!
`
`Universfiy 0? Leicester
`
`fincerpurafied in the: United Kingdom}
`
`University Quad, LEéfiES‘E’ER, LE1 ma,
`Uaited Kiagdom
`
`€72)
`
`invenwris)
`fimathy ’Paaa? £26395
`59hr: Lees
`Peter Ciifi‘ Wifiian
`nerek Farina;
`
`(54} $933th far Eabmamry afiimais
`
`{E7} The 5303mm (1) is pmvided with one 0r mam stnrage bins (9) farming part 0f me exterim a? tines £3933th
`('5 L the bins being issiated fmm {he interim of the iaciatar by openabie iids {12) arad fmm the exteriur by
`upenabfie dams (14). Any items inside the stcrage bins may be manipuiaied by gieves <8; and sfleeves {4}
`pravided Era the frcnt waif a? the 5302mm Cages (3) for Musing the animass are afisc: pmvided,
`
`1
`
`Fifi?
`
`
`
`V88%QZZZ33
`
`At ieast cna drawing Originaiiy flied was lnfmmai and the mint repmducad fiara is taken fmm a Eater fimd fermai came
`
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`
`AN ISGLATGR
`
`This inventien relates ta an iealatar to be usafi
`
`for the isslatien 0f laberatery animals fer use in medical
`
`and pharmaceutical research and the like“
`
`Iselaters fer laberatery animals are wellwknown
`
`and are used to previde a nanniefective envirenment fer the
`
`animals by iselatien and previsien ef a filtered air susply,
`
`as requirefi for meaningful experimentation“
`
`These isolaters are generally made 0f clear
`
`flexible PVC film material formed t0 erovide a sealed
`
`envelepe¢ This envelaee is suspended frem a metal framewerk
`
`and carries sleeves and gleves prajeeting inte the isolater
`
`whereby precedures may be carried out within flee iselater.
`
`The intarier Of the iselater may be held at
`
`pressures higher as lewer than atmespheric, aceerding to the
`
`nature of the werk in hand.
`
`Animals contained within an iselator are generally
`
`held in ca es meunted on the back wall. Manipulative
`
`sleeves and gleves preject through the frent of the iselator
`
`late a gap between the frent anfi the cages. This gap must
`
`be kept free 0f obstructien to allaw manipulation 0f the
`
`animals and equipment, This leads ta a lack of sterage
`
`space in which to keep sterilized food, bedding and the
`
`like.
`
`10
`
`15
`
`20
`
`25
`
`
`
`2
`
`Furthermore,
`
`the iaeiatihg requirement 0f the
`
`iselater leads t0 difficulty in intreducihg bulky feed and
`
`bedding into the iamlaters withhut breach 0f the ieelater
`
`eentainmeht.
`
`Te date this has been achieved by a leek
`
`f
`
`i
`
`Chamber ceneietihg hf a length ef tube sticking in from the
`
`front well, each enfl ef the tube being remevably cevered.
`
`This ie rather inconvenient, has very limited (if any)
`
`storage capacity, and eeeubiee space in the free veiume ef
`
`the ieelater which ceuld better be utilized fer
`
`10
`
`manipulations.
`
`The breeeht inventien addressee theee prehieme,
`
`in the preeeht iaoieter the fleer of the ieelater
`
`is at least partially replacefl by eterege bihe having lide.
`
`When the lids are closed,
`
`they are generally flush with the
`
`15
`
`fieer. Therefere when the iide are eleeed the interier ef
`
`the isolator has the same fleer Shame available he in
`
`traditibhal isolatere.
`
`The bihe may run along the length Qf
`
`the eage and to a dehth campatibie with the reaeh of the
`
`gloves and ea opening the lies gives aeeeee te a
`
`29
`
`canaiderahie eterage velume,
`
`Traditiehaiiy,
`
`ieelatexe have been made with the
`
`eaveiepe farming a eemhlete “bubble“ including the fleet of
`
`the ieeiater. Thie weuid make the eenetruetieh 0f the
`
`T
`
`fieerwmhuhtefi bins impractieai.
`
`The invention therefere
`
`25
`
`embraces the eanetruatien ef the fleet aha eterage bias as
`
`a ehewbieee basemtray far example ih glaaewreinfercefi
`
`
`
`3
`
`plastic so that a smooth, radiused, easily cleaneble
`
`interiet is preeented“
`
`An envelepe, or cemepy, consisting
`
`0f the ceiling and eifie walls at the isolator is then sealed
`
`gaemtight t0 the edge at the beeewtrey by wrapping the
`
`eenepy areune e lengitndinel peripheral flange meulfied es
`
`part of the besewtrey.
`
`It is then secured by a eentinueus
`
`Umeheped preerietery strip pressed ever canopy and flange.
`
`It is a further abject 0f the present inventien to
`
`provide a meene fer intredueing supplies of feed, bedding
`
`end equipment into the isolator. Thle is achieved by
`
`yrsviding doors in the besemtray to ellew cemmunieetion
`
`between the outside 0f the iseletet and the sterege bine‘
`
`The sterage bins are new previded with deere fer
`
`cemmunieetien with the exterior and lide for cemmunieatlen
`
`with the interior. Thie allews the sterege bins also t0
`
`function ee leek Chambers.
`
`In Greer t0 better leelete the
`
`interior ef the ieelater,
`
`the aware and lids sheuld
`
`ereferebly clese te farm a geewtight seal~
`
`In a further embediment 0f the inventien,
`
`there
`
`20
`
`are baskets previded fer intredueing items into the
`
`isolator.
`
`The storage bins may then be farmed t0 be of a
`
`depth toe great for their bettems te be accessible by the
`
`gloves.
`
`A basket containing the items ie new placed in a
`
`eterage bin.
`
`The tag ef the basket may be reachee by the
`
`glevee and so the basket may be liftee inte the isolater
`
`wherein the contents ef the basket may be removed.
`
`
`
`4
`
`A preferred embediment of the greeent inventien
`
`will new be deecribed with reference tn the drewinge.
`
`”-25“
`
`Fig l is a partial vertical eectien ef a preferrefi
`
`(I!
`
`10
`
`embodiment of the present inventien‘
`
`Fig 1 shows an ieelafior 1 having a canepy 2
`
`eealed at its bottem ta a beeemtrey 8 by a Uweectien
`
`preprietary seal 10.
`
`The iealeter centeine one er mere cages 3 fer
`
`hanging animeleu
`
`Sleeves 4 and glovee 6 eealed t0 apertures im a
`
`frent well 0f the canopy 2 projeet into e space between the
`
`cages 3 and the frent cf the canegy.
`
`The beeemtrey 8 previdee e flaex for the ieeleter
`
`and includes several eterege bins 9 which are paeitianed
`
`a": U“!
`
`belew the fleer,
`
`in the gag between fihe sages 3 and canepy
`
`2.
`
`Each eterege bin 9 is previded with a first
`
`epenimg 13 at its tap which is eloseeble in a geewtight
`
`sealing manner by a lid 12 which when in paeitien lies
`
`EC
`
`generally flush with the flea: of the ismletor. Thie firet
`
`epening 13 allows cemennicafiian between the eterege bin g
`
`and the interim: cf the ieelater.
`
`Furthermore, a side wall cf each eterege bin 9 is
`
`provided with a eecend epening 15 which is cleeeeble in e
`
`.7“
`
`25
`
`geemtight sealing manner by e dear 14. Thie eecend agening
`
`15 ellewe eemmunicatian between the sterege bin 9 and the
`
`
`
`exterior of the isolator.
`
`U!
`
`In a first preferred embmdiment of the invention,
`
`the arrangement is such that glevee 6 and sleeves 4 allew
`
`the manipulator te reach part ef the eterege bin 9.
`
`in a modificatien,
`
`there is a basket provided in
`
`the eterege bin 9,
`
`this basket being leadeble via the second
`
`epening 15 ané having its tap at handle manipulable by the
`
`glevee 6 and sleevee 4.
`
`in such an arrangement the bottem
`
`0f the bin neefl not be directly accessible t0 the
`
`10
`
`menipuleter,
`
`The invention is further directed t0 e methed Gf
`
`ieeletienelly moving One at mere iteme intQ at out cf the
`
`After making sure that the lid 12 is cleeed,
`
`the
`
`Gear 14 ie Opened.
`
`items are introduced into the eterege bin 9 via
`
`the first epening 15‘
`
`They may be sterilized by treatment
`
`befere er after being SO intreduaefl.
`
`The door 14 is closed
`
`end, if necessary after a delay to eneure Sterilizatien,
`
`the
`
`20
`
`lie 12 can be epened and the items used“
`
`The teatime is
`
`reversed to dieeharge items frem the isolateri
`
`The above method may be adapted fer use in the
`
`modificatien of the apperetue by intreducing the items into
`
`the basket in the eterage bin 9, Q: by intrefiucing e
`
`25
`
`preleefied basket into the bin through the epening 15.
`
`
`
`f“3’ Pi Kas
`
`'('3
`
`O\
`
`1.
`
`An ieelater having an eneleaed interim: including
`
`a haeewtray part ef which is a eterage bin, said storage bin
`
`U}
`
`farming part 0f the exaerier 0f the ieelater, said ataxage
`
`bin having an apening inte the interier 0f the iealater and
`
`having clasure means fer separating the storage bin from
`
`the interier.
`
`2.
`
`An ieelater aaearding to claim 1 wherein the
`
`eleaure means gravide gaewtight iaalatien ef the storage bin
`
`frem the interier.
`
`3.
`
`An ieelater aeeerding to claim 1 er claim 2
`
`wherein the eterage bin ineludee a eeeend apening which is
`
`ta the exteriar 9f the ieelater, aaid Second epening
`
`having eecend eleeure means for separating the Storage bin
`
`from the exterior.
`
`4.
`
`An iaelater aeearding ta Claim 3 wherein the
`
`aeeend closure means gravide gaemtight iaelatian ef the
`
`storage bin free the exteriar.
`
`20
`
`5‘
`
`An isolater aeeeréing to any ene of the preceding
`
`Claims and having a manipulate: operable from the exterier,
`
`said manipulate: being prejectahle inth the etarage bin.
`
`6,
`
`An iealater aeeerfiing t0 any ene 0f the preceding
`
`claims with a caneey having generally vertical walls and a
`
`tap,
`
`the haeewtray being a discrete entity sealed ta the
`
`bettem of the walls.
`
`:3”;
`
`at?
`
`'a
`
`,3},
`
`
`
`7
`
`7»
`
`An ismlator accarding to Claim 6 wherein the
`
`canapy and the clasuta maans are generally trangparent.
`
`8°
`
`A method far isclatianally moving one or more
`
`abjects into an isolator, said ismlatgr having an enclcged
`
`intatiar including:
`
`a basewttay, part 0f which is a starage bin
`
`forming yart of the exterior of the iselator;
`
`a claseable lid in ardet ta iselate the storage
`
`bin from the intetiar; and
`
`10
`
`a cleaaable flag: in Drder ta isalate the starage
`
`him from the extaricr:
`
`said methafl having stepa including,
`
`in orfier:
`
`~
`
`w
`
`m
`
`m
`
`m
`
`Clcsing the lid
`
`opening the door
`
`introfiucin said abjects intc the Starage bin item
`
`the Exteriat
`
`clasing the dam:
`
`Qpaning the lid, and waving ane at more of the
`
`abjaats upwardly inta the igalatar.
`
`20
`
`9.
`
`A methmd fer isolatianally waving fine or more
`
`objects Gut 0f an iselator, said iselator having an enclasafi
`
`interim: inaludinV:
`
`if
`
`a basewtray, tart Qf which is a storage bin
`
`farming part of the axtericr Gf the isalatar;
`
`a closeable lid in arder t0 isalate the storage
`
`bin from the interior; and
`
`
`
`8
`
`a clcseable door in arder ta isalate the starage
`
`bin
`
`fram the exterier;
`
`said methafi having Etaps including,
`
`in arder:
`
`clmsing the dear
`
`US
`
`opening the lid
`
`intraducing said abject$ intc the sterage bin
`
`dawnwards fram the intariar
`
`closing the lid
`
`ayening the daor ané removing the abjects from the
`
`1Q
`
`13.
`
`Sterage him.
`
`An isalatar Substantially as herein deacribefi with
`
`reference ta the drawings.
`
`)a
`
`
`
`vatenm Act “53??
`Examiner‘s mam": m tha Sampfimiier under
`fiec‘tmn $2? {Tha fieamh Repair?)
`".55 ,_
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`fiefiavWfiTmhcaifis
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`’ Search Ewing?
`
`Awiicatian number
`
`GB 93053?5.9
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`
`
`(DUK CHEditim L
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`AER. (Rm; 54g;
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`(35?
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`flafiabasas {$98 ever}
`{E} Lax Patent Gfiice
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`{a}
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`ONLENE QATABASE: WPI
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`L v THQMAS
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`25 AHGUST 1993
`
`
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`Becumems cansflderad rafievam fcifiawéng a march in regpem a? ciaims
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`1""10
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`(3% (war;
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`ta mam!“
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`mmgmieg a? mam H H
`X: fincumgm indicaténg :an cg? neveity 9r 9f
`invamive stag.
`
`Y: flagumam imficating Rack :3? inventive step if
`cambmafi with me 92' mare mmr dacumanig <3? tha
`wme categery.
`,
`.
`,
`.
`A: Emcumem undacatmg technamgmai baskgmund
`andiar state a? mg mg
`
`
`P: flesumam pubiishm an m after the dammed
`priarfiw data but bafara the fiiing data a? the
`praswt agpiicafinm
`
`.
`E: Patent dscument gubiished an a: after, but wath
`primiw data mriier than, the fifing fiate bf the
`mawnt ggmimmn.
`,
`f
`.
`&. Mamba a? ma sama patent amsiy,
`mrmgmnding fincumant.
`
`fiatabamg: The UK Patent Qffiaa ambafie cammfisag aiass‘éfiad mfiflwigm 9f 63, EP, WQ mad US
`331%: smcifimfiam as maimed parindiaaiiy in the Qffic‘iai Jaumai Wammé. “rm mama éatabasess
`”msmema far march ma aim Eistad narifidicaéw in tha Qf‘ficmi éaumai iPmamgL
`
`
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