throbber
JP 2019-506861 A 2019.3.14
`
`(19) ELAREE@SFF UP)
`
`ana RH BH ZB RA)
`
`(Li) PREeR
`#93R2019-506861
`(P2019-506861 A)
`G2) 236 323123 148 (2019.3. 14)
`
`F—VaI—P Be)
`Gly Int cl.
`4B063
`5/071
`CL2N
`(2010. 01)
`CI2N 45/071
`4BO65
`5/074
`Ci2Nn
`(010.01)
`C12N 5/074
`
`C12Q=1/02 (2006. 01) C129 1/02
`
`
`C12Q 1/6851
`018.01)
`ci2za
`1/6851
`Z
`
`CI2Q=1/686 (2018.01 c12aQ 1/686 Zz
`
`
`
`
`SRR RAK PIRBRRK RI (ef 107 B) RRR ICES
`
`ZNA
`
`Fl
`
`H(7I)WERA 514135801
`45%R201 8-540028(P2018-540028)
`Q)) HBR
`YH RHR PE AKA ee
`3 pe29282FLA (2017.2.1)
`86) 22) HBA
`
`(85) SHAR SHEA 32 BRS04E9A28 (018. 9. 28) a~
`80) BEES ESS
` PCT/US2017/016098
`PAUASRE AURA we
`87) BRAMBS
` woee17/136479
`SEA KRU FAIB77
`87) BISA RA
`5B Ae29268F108 (2017.8.103
`oOo
`GD MABEBSS 62/289, 521
`TH RBA 100102978
`82) eB
`3B AE28262FL (2016. 2.1)
`Bt ek We
`82 RFXABERA
`EE (US)
`(74) (REBA 100162118
`SI RARERBE 62/332, 849
`Ft BHR
`82) RAE
`32 928255AGA (2016.5.6)
`(THREBA 100160923
`G3) SWeBERE
`xB US)
`At WC eee
`81) BeBEBBS 62/354, 040
`(7 KBBA 100119507
`32) @AA
`32 PR284F6A 236 (2016.6. 23)
`FHL We
`G3)RRBERE
`26 EB (US)
`FR CES
`
`THR
`
`64 [RR OSE) v4 7 URE BCDC ZBMRORB OR MOD ATF LRDAE
`
`(57) CHER]
`Iga oy ik, ASR USSEIARE EPL
`fhe SheMic, Vf Pu ARYA ROK Y LONE
`
`“EAAAMAWEIS EST SOON 4 7 AE CHS, ©
`a1 OVI BUY T PED ENE RRL PRO
`WAU TUS. ARCRES SRE fi oS Nhe
`HN OD BSS ADRNODSREYZo Rs & AruAl TS
`FAG. MRSS SUC ROL SORETEREPERR
`
`
`OMI NABIC LCS, LPL, FPO RA
`th, 4EHANICRET SP NRCTOU SP S47 PRG LTB
`BY, BURNIE RO LIN bhU-tEAUTHEOSY, RE
`
`, SRE EOLOeAAFORE OPE EL
`ww,
`1 BD ROSRROUAINA Bes i PS CHPEO EL
`OMENS, BOREROSINTEREHP SCE CL Ett
`TRBE PU UV Pe aREIC TS,
`CSGRIM] Pd 4 0
`
`Figare 40
`
`
`
`

`

`(2)
`
`JP 2019-506861 A 2019.3.14
`
`
`
`Cee at Gok © 8 IAD]
`Caeck G1 J
`He A A 4e eR PT SAE CRT,
`
`
`VOPEYARUWn t SAOPAF COPS COR BIC KSINR OE mR,
`FGF 4, BUWnt 3A#KMUCHIRGADBGO2LOWSF APOE FCOMAAN
`BOW BIC KSBOFik,
`bkRAD A YFRRU ER Fa -PFORIR,
`Nf
`bLRADV eV FRM LR Fa -POVvEPUPCOMM, BAC IC
`CHIR9RV9O2Z21, 4ZJ¥Y. ROEGFOP FCHBRULTB Mie e rR STE
`eas. Wa ITE.
`( S82 2}
`amd i PS CAL UYOAF SS YEH U VON TERRE B AN SG ce © 3h 3S AE PE 8 AH Be
`CLOL~i PSC) GH4\. RW 1
`lc aRO AR.
`Cah 2k 43 ]
`Wid i PS CA. BIEMIBRBRUSY ERATE EIBHE IC MRL TO AWK SEK
`
`UPUFSAYvAkH PMCHS. FRI 2 tc HMOKE.
`Cio eR WR 4
`}
`
`
`PIFEYAROWnt SADE R TOL PS CORA. HI~4AM CHA,
`RIN 1 Ca RO BK
`Cis ck a5 ]
`FGF 4. ROUWnt 3AKRKRMKCHIRYIVDOZLOWF NAOT FCOMEAATIE
`HOW RA. Mi ~ A AM CHS. AAR DLL ac OAK
`Catk I 6 ]
`
`CHIRGR9OV2Z21, J¥Y. ROECKF OPER COMBA, H18~2 1 AHO
`
`HC SL RAOR IR 1 eo ac ROD ATE.
`
`Cea ok 17
`Hi ac AH eA icp REEL CD38 264+MIC MOU CHH TS. MRM ii
`INO FTG .
`Caiok HS ]
`ad ac Bi Mh ae. amon ic, ROCKS AOR PCH TO. GRIN 7 ioe O
`IEo
`CioR HE 9 ]
`RacMASS ROCKMBA, SB202190, KUABSS-O1IOL9OKLES
`ts HY AC PR 4S GOK LT toad aK DIK
`Cai k Hi
`1 0]
`Bis HM OS RICH ME GL AOR Ic ac RO TIL.
`Cia ck At 1]
`ARE TICsO Ric ko CNM Ske ao MD.
`Cask IR 1 2]
`aR Lloro Rico ho THM ENR Me BOATR
`Casok BE 1 3]
`
`-
`&. HRI 1 2g ROAR AL TP,
`
`Ls
`MeMRE L fe Mk
`Caaok G1 4]
`am WSfeTEP MDH etk SE SA
`
`HOMO AS he thee MN Ci P
`
`LOWEONM FORE F CHR ST
`
`t+
`whee
`
`NNA
`
`CA T.
`
`C) FETE ST S
`ae
`
`tt Tv
`
`RE
`
`10
`
`40
`
`Bee AR
`MI OMEOWM FAS.
`Cia ck It 5]
`PIUFEYAROW nt SARE
`
`N
`1 PSCHeALEBSATE MCE SL WAC AR.
`
`cf LOM EOR FORA CI BT ACK EO, Bi
`
`
`

`

`(3)
`
`JP 2019-506861 A 2019.3.14
`
`nmi PS CeHMANRRE OB aHE AX US. MORI 1 4 ic ROA,
`Cao-Kk TR 1 6]
`
`POFPEYARUW nt SARRPOILOM LOR FOGA COM BD. A SAM CH
`. HORT 1 5 ic sRoOAE,
`CoRR 1 7
`Aj ac 2MES i PSCA. MM. Mw
`EH ey yp He orRLSR TR OR GH BS 01, BELT. mA
`WH Se 14S.
`FORTH 1 6 kc ROA,
`C #8 3k IE 1 3]
`
`
`
`
`
`
`
`
`
`CHIR9RVO2Z21, FGF CFGF 4), LDN. ROLF/Y TYR CRA) #82
`LDREDA FOP FCS SMI R TAT LEO, RAAB eR AD ea RA
`e’a{e ES. GORA 1
`5 koe OWIE.
`Cagck ta 1 9 ]
`CHIRO9RVO2Z1tL FGF CFP GPR 4). LDN, ROVF/ AYE CRA)Boas
`LOR ELORFORE FCORBA, NSAM CHS. FRA 1 8HRMOAK.
`Ci oROY 2 0]
`
`a- Fae VYVPEMERMELOCMBT SZ TCHI HOD. MMB AD ec Oy Re AB ERS
`&e EUS}! MRM 1 Sk eMMoOAL,
`Ceo Ta 2 1)
`
`
`
`
`
`1 OUELOR FORE PCOS SE SMB oT, hi
`€8@8
`REMREAF CEC F)
`
`
`AM ADP eof REAR ERNE DHE EUS. HOR BLL 8 HERO.
`Cie2k G2 2 ]
`ba
`€8U 1 DM ELONF OPA PCOMME SHAR BD. H 2
`RAMBAF, CEG KF)
`QAM CH 4. FR 2 1 es ROAIK,
`Cahck2 3]
`aiad i PS C#. RMlc., ROC KMBALY 2 7
`4 RRMOBI.
`Ca§ck IR 2 4 ]
`LONI SS 189RUS B43 154 24280 1 DMEONAF ORR CHB TZ
`BlCk OL Wade i PS Ce PRAWN EDIE HRS. BR 2 BC RROAE.
`CHR G2 5]
`
`cp Ct DRE OWMPFORT FCOmAD.
`LDONI93189RUS5SB43154288
`W2RMI CHS. Mok 2 4 lomo AK,
`&
`C#esk 2 6]
`
`PSY CPMN) ROILWR-endo®
`Abr RYE PY TPH ARSAGCL FHRENTD
`
`
`
`SterioyeOwW Sov e FCRRTAT HICH D. Asc ANE ANA Ee ade
`
`
`kH#S. HRM 2 4lcoMRMOBK,
`COR 2 7 ]
`Ab-RYEPAAABRS AG, FUMENIPSZY CPMN) . ROTWR-endo
`
`ZA DO LOY ELORTFOGE PF COMBA, M5O~6 HM CHS. BRING 6 CR ROA
`
`nD 32 ORE RCE TS. WRI
`
`
`
`
`“I
`
`Caok IR 2 8 ]
`DAPT, b#/VALHB CRA) AL DMEM FOR PF CHB 4e2ceED
`
`. ASU DAN 72 RPA KS. FHORT 2 6 CaM OAK.
`COR 2 9 ]
`DAPT, bD#/4VB CRA) SPOIL DR EOR FOE FCOMBD, H4A~ 5
`
`ACH 4. GRIN 2 8 tc HRM O ATE.
`C28 -RI 3 0)
`BDNFEF#@OD1IDMEOMN FOUR FCMATSZ CLICK OO, WARRe &
`SlCmRRA CHS. HK IN e GicCe MOAR,
`(Hise TH 3 1)
`
`10
`
`40
`
`

`

`(4)
`
`JP 2019-506861 A 2019.3.14
`
`1 OR bLOR STORE PFCOMBA. N20~2 7AM CH 4. gk Ik
`
`BDNF @&&@t
`3 OK aeRO AK.
`C#isk DE 3 2]
`
`(2?
`SEOR TA 1 4c ac MOAR ic Ko TT BS fh ie Bi MR
`
`
`np%
`
`a. Fe UL we
`
`i PS CORR
`
`I C
`
`muswh
`~
`
`&(FSon~ =o.
`
`Cc ert
`
`askI 3 3)
`acRUTR 1 4c RMOAR LC Eo TMM A NEHA RF Roa HOV ee. Pie LR i P
`S C 0) A AK,
`(sek G3 4]
`(AMA PU DY PORECH oT,
`EODILL ERG SRE Mi Ci PSC) RET S
`-i PSC#, 1DEEO( AMER MS tSETE,
`[Li PS COIDMLOMMAM ET ACE
`ea 4OD
`x xin“
`
`(4 te
`
`Hil
`
`hoY BU YP BERR O kb ete GOK A 3 5 tc ad aK
`
`10
`
`40
`
`ci PSCOMIODMAEORTEOMEA, BMIOMEDOILAWOR Re Hae ¢
`@. Apa te.
`(#8 Kk 1A 3 5 J
`[eGwMAPU-AYVYAR, AGWRE DOM TOA, U-nA VP RSE, MR 8 4c
`adeK OAK os
`CHK G3 6)
`Aah 1 OMEOU AG MORBA. NP - kK BOUYBLae BRST 40k eeBo.l MORI
`35 lod O AL.
`CeskIN 3 7 )
`Wad 1 DE EO a oO RBA.
`OAH.
`CHK TE 3 8)
`Mal i DIA EOS MORBMAD. SCO2., POLRMT, TFAM, ROCYTB5
`AYOMNEOVMBOW De SOL ARIS 5S cH MOARK,
`Cah ck TS 9 7
`
`qHigdafe Lv i PSC. WBE CHA. FIRINS 4 cH RMO AE.
`Cok 4 0]
`Me atk Le i PS CA. MA PRFMBia-oYy CHS, BRU 3S 4K BRRORE,
`CFE HY OD eee AN Ze aE HAL]
`C$Xfit ap BY}
`foo0oo1]}
`ASEM. AI Rev PTO RE OMAR DUIS 6, KORA,
`S2 FRAG Belo oto. APE. RRL MOYER MAE DES 4MeO OM
`fa eR LRV A POR AG yy Fiche 4S We Relic CL He MH lk, HES
`ATMChi PSC) CHO, BAMA. MBMMCHS. Kono eM ERIC BL
`SB
` RWRORMO PRM RICO CHHABRA ORR SWS T SHR RECOMR
`ROA RELIES PA CE DC) OP Ricow ct, SRB Fy Oe RT So, Ble
`
`#€ +EPEO BR CRE PAPO 3 NFa Vices 4. PMU SEE D
`CRRO©O A RRA RU Ry 2 MEP T Sheol, MAR SRE PE REM Ne Ch i PSO) OF DO
`CMTE DHEU SH, SLT, EDCAOFHMES MIRT S EADTGy bh an-AeE
`
`=
`LCBWD.,. CLT. CSR ASMIB RBC. IPMS SED COMRAR GE
`
`
`¢ Sf oid, MMAR Si PS MeL Fy VicmMm se oS
`[00023
`
`XB, AHH. BANA PP Ci PS CHMROANH YT AE) HKROMM SS
`Saktkt vy PkICHBTBZRMOATROY APF RITA, SSE Bice. OX
`SAR AAAL PLA UR. BRL ee Me Fv Vic Bans 8 pp OE WOE REI BOT
`
`
`

`

`(5)
`
`JP 2019-506861 A 2019.3.14
`
`VI7OMAM SH y Flt. cb BIRR. MAI. IBD ESM S,
`C#5 te£2 iy }
`foo0o3]
`
`
`PRA ORAGH Mic pwc, ALM CH SAR MIRALIL EMA CE DC) &®RLN
`Wek blOM LCT RRM AN cB ERD SEL IN op OA RRid SKA fa Ic BUARMRRARHUR
`ORR ISE RRR SAG KN, Cals, whan bee » AfaAMict. HR
`Ba A op Bes HH fk BLAKE ORS KR & RATAN. Hic, BLOM omML CHE
`OPLA. MA PR CHT) 2a-aN7 FRM o ara ylt, BSHHROAARY
`
`
`
`YROUFL UY. BARON PPRY Y FBOO-MBP SCARBhY FP LES, BR
`fEE RU RRKAROWMRe ER ST, Liew TCT, EDCHLYOKN SKIMMER
`
`
`10
`
`
`
`yg
`
`lCkRSZRSPORM I. LGW NASER OMRERSICBOCT-HORBS RELI @hte
`
`KO, FRIES RON a eMC LBS.
`fooo4]
`RRA VR PSTE RPP Oe RAIPUR BAT 4S EMR UR Fe OTC EMAERHM AE ROL CE
`
`D C ® 94 BH ABRR58 A Be OF LARC WL RE AR Ke GETOE OH BPC BL
`F~-BISRPAD Oe mnB4petmAGbwes SR Hilo. RIAA Ol, Ch RES
`fe PEE AN Ch i
`SC) # EWI UL CT. FEE © BR OBER EAB RE SFB = a
`
`ICR S SII RE ED CRB OA RPA U RI PL FEA COE D C Be ee % Hi
`
`WeSPSvy hv eH heUCR ETS, CHA, SRSA OL FOLSGORRH
`OSI HS!
`tooo 5}
`MUNG CE TERIOR Me RIE SP. MRED CK, ADPwMMHMemee i FCERUCUIH
`
`TNK BU ANF K BY APN Be BUS aA Le. RMR ic, ED CMB, Be
`Bt. SkUY FU SY OMRON F-~ «x BARSPMe TLC. RhOY RDP ARLAM
`Am AAEMOTPGCEROIHTNICBUSRADO ST bhUY EU 7 BER O F fal OP OR RE
`wet PERL BESO.
`HBR CS COB. TFAM, POLRMT) ROUSRFUYFUYF ¢
`
`Cy t BS) MaA~ ELEM RB FORAORRE MAK. NE — k BRAM AUC 3 @ S
`Oe ED CECNP —k BY AFIFVRBeERILL Sh
`re LeteLy Ble SDWRAL OER YE FOLIE TD enpie wn NF—«B
`VR UP OPI eee le, COMMA SHRI, Ch SATE RR MH CP SC) cdo
`CR FOE Os PER Te WHE DCN ZERMCR BAD Yon PL
`
`VOPNBHROS ROY PUP IRRER SLEW TPT SZGED CORB SEB Be RUTH Ss,
`
`FT
`
`FuvbpWA- LIMO EMEC EOTHS!,
`CAS AB >ARE YS
`fooco6]
`
`ASENAIk. HBSBOiL UMS REM Ae Ci PSC) £HE ST 4TH, HRa te
`Liki PSCw# 1 DMEORAMEL BM EH SCHR. Tithle i PSCHOLDYMEORE
`eRe TAC EPBA. NMBAELKE i PSCMOILDYEMOR WOME.
`1 DIM EMOTE
`GOR MERE TS. (AM APU-AYFORRARERT S. - RMRIC eT,
`
`“RI GwM ASU -n VP, ADMIRE APU -—nm VY PT ACL ABE, SEA Re
`
`<M BWOT. SRI DMED( AMOR MI. RAP AY SB CONF xB) OUYVBRE*®
`
`Fe hey nner ee eee i ibae oun
`db CP EY E-PP RY TU RVR Cs 002) ~~ RNABVAD—CVRhROUY FY
`
`D7 WRU A fk sb zeaS, SEH HB iT DYALOEA MO mae Mis, Yb ao
`
`F (CPOLRMT) . RBEWFA, SbhUY PUP CTFAM) . RUCYTBSO1D
`
`MhLOVH OMD>e Be, —SHBR Bloc. Maca fek be i PS Clk.
`HW ER OH
`
`&, ~RMRBE Ilo bwC. MeO Le i PSCK, AR PMoaK- oY CHS,
`f[oo00o07]
`ny
`
`ASEH IK. GRU SHE TEP RDN ee ke Pe SAH CHT. HARO BM S Pap AE C
`
`iPSC) #HHET4ch,. BEE,
`I1OWEDA FORA CHET ATLABA,
`1
`
`40
`
`

`

`
`
`RicBwoc., 4HRmiPSCH. VIF PYVAROW nt SARBG IMM LOR FO EE
`
`
`(6)
`
`JP 2019-506861 A 2019.3.14
`
`DMEOWRATAL i Pee CEA CES. HMACRRA TS, — MH
`PGK MATE TC, mpreree Fafk dd 4, — HMR ICBO TL PTFE VAR
`OWnt SA# RE 1 PAE OEE O48 EBC OS REE IK MZSHARCHS, —He
`Hel SVT.
`ORR WIC. aie U Te Aa 1 POS C 7% BR ath HE fF Pe BL HEV C .
`an ee US
`-SoWR Ric isc. SRE AAR RIK. CHI R99 O21. FGF CFCGF
`mee,
`4), LDN (97) . ROLFY AYR CRA) £81 DOR LOR TF OPA PF CS
`RIweXk NAT EC. WMHAVP roe RN EDT 4S, SH Reto bet. CHIR
`99021, FGF CFGF4)., LDN, ROULF/YTYEB CRA) # BO 1DM EO
`
`~RHMM Hic BWC. SMM IAT om
`IE OTE SEO EUR EES WMSAM CHS,
`ft F§
`ae FH UVAE AREMECMBENSCE GC. WOR ER N&O ied 4, — Sie
`
`FRC. HMM AV roe Bik, EX MEAT CEGF) &@8@2 1oWkhogt
`OPP PCOS SRSABlco kot, Wh LeN eat So. HRM RR CBT. LR
`
`
`RRA CEGF) @#8 0 1OREOR FORE FCOS SR S6E4MNBE. W201
`
`a
`
`
`
`
`
`
`
`
`
`
`eeee ee Ne Te eee
`431542888 1 DOM LOM FORTE R CIPRENSTCE CL MRAMNGon
`
`
`-HMB HBT. SRMi PSC. LDNIO938189R8
`
`
`{ee PF CBT S64,
`
`
`
`
`A, —~#MBREI Biot, LDNIOSITLS8BORUSB4 3154288 1 OM EOR
`
`FORE PCO“ MEM Rl. HM 2HCHS, HRB Ric BC. YK OR OE Elk
`
`Ahb—- RYE P TPH ARS AGL PUMENMIY RY CPMN)
`. ROIWR—-endo®
`
`
`
`
`SeOiIiDNMEMOR FOP CHR ENST EC. IOAN EDT SO, RT Ric
`BWC. AB-K-AYEP TAZ ARSAG, LEvoIy Ry (PMN). RUOIWR—e
`ndo®eO 1 ONL OMT ORER TONER. WS ~ OAM CHS. RAH
`
`Sra
`
`
`
`
`
`
`
`
`BWC. SRAM. DA PT. bDRYAYH CRA) BRO LON EON FO
`
`fe RCMB CNSATE EC. MEATS, ~BMBRBlicwbwOT. DAPT. LDF / TYR CR
`A) #80 1D LOR FO@RR COS MIB, NH4~SAM CHS, ~-BRMB Ri
`BOC. “4 ERIANG Ik, BDNF © east DY LOR FOF A F CHR ENSCE
`
`CGC. MEATS, —- EM BRI BwoT. BDNFe Bi DM LOR FORE F COMMS
`Blk, W20~2 7TH CHS,
`foo0o0 sj
`
`oePMALE FA CE DC) A, MOB e a eMC TCE, BSW, FRC H
`oT ODL LEMOS MEbO ee eafoe ch OwnFnDic kot. ROYER
`
`CHE CH SLBA STH SB, MAIR. AR AEL MSR ER HEL ERE INR AREL FEE
`
`
`
`(RMA ELSE PIL ROA CRIN RSUB eT eMo PT Ck kot.
`RRL ARE ION LCR RehPt, PROB, MAMBOMcC BOT ee CHS
`&. PRENS, BMA 1L ICR. CHE OMREL OB OMOWTMES.
`fooog]}
`SEM BOK, ADWHALIEY MM CRED C) AOMMN IKI BIREBD, Fb ON DR
`
`MROWMH ERMC BOTHER CH SLORMRMR UCHR.
`XK Sll, WAS, ZEOK
`
`3S 7H BR A AMIS bIY RU PRRE RS eee oR RETTIETEONF-— «x BROHMG &
`
`VON 7 BRIERE ME DS PPB ECD SLR LE.
`
`footio]
`FU VIFVIRGRAB ARE EOS RIR CI BD) té. © b OW © 18 tb xs FZ TF
`3, FER MO RERUN AE, BR RO eK) © FB @ Be OBE eA OE BY
`rho Cs RRC XNAL HRA EHEWZAIBDORMCH SEZ, ChOWUREHAMicb
`WECHNSORRSZEAROMWM RS SHE T STEER. CNSBOKNGA—-ROMWUR
`He ORI 8 6 MR RI ERE E PARED PME C Hole, CORR. &
`
`KAGE BROMFOE Ti, RHR COMB LAMB OMe. Fred, RES
`DEEL KMERO EENCOMBOCTHUPCHELTOS. BOMNE ARE
`
`
`
`
`ee SE, CMmeEenowRHM Ye bon, ER LBD OWEN YMA BRC CS
`
`10
`
`40
`
`

`

`(7)
`
`JP 2019-506861 A 2019.3.14
`
`
`
`
`Hl, EObU. FLU bh CHBLEMS ELEM Md. MED ke ROLE OL MR eM
`EULHEO. HSS. EN SHOREHAM SMT SCE MDCE AY,
`foot}
`he BS Foy Fx, MRR ROR OE HECA AUER AE EP VET SRB, VTA RA- Be
`UH ROY VANACH AMER BST oR OOVA TORRE CHS, Fv VON RR
`NAc REIS HEF. TREE RIN RD OMBOR Dic, HMMM HST SLA A
`SIS 7. BAL ROR ea OWN A OM AAR SORE TS. ASE GR Bes,
`WOT SAMA TEEeMCeL POL LB DRREMA RIM T ARR OTHE OBR
`Oma (GE Pe. ROHR. MEM) SP NICMAID OED CRSA TRA Fy OL) A
`SET ARDC, MKAANPRMN SBA EUSZTEM HBS, TCHEDOAMNOR MIC.
`TE
`HOG de Clk, SHAR AICHE SY GIL AV RNR ORE ROM MA EO fe fe FOC REL
`Reb SW EM MH CC aco 2) OMMIC MAL THOS, COARKIAL eee Nie
`U7 MRE. BRAS bk eo AP 4 5 OE. ROUT OMe TAL DO Le
`
`RRO 4DFNC COUR RL Nw. ROR b) CBSE NKEMEOH RE
`Bp RElC TS,
`fooi2}
`4
`LaALR MAS, BF OAM COBER SGA Aik. Caco 2 Higa COMR. JES
`ELRUP RAP we Bem TEKH A, LERaT. RABRBOUDT RA Pics oe AME
`RO ERIRGT UTR ATV ORBEA ST STEM CE EY. MAT. Caco-
`2Mhigtk.
`I BDIicssRS SLME CUM SANTOS RFBEROL KN hU- FEL
`
`
`CHEF, SNic kot,
`I BDBMEA FORMS e€E SIH MST SRASA MEETS
`
`o HBC. BOC P it, MRA CHAIR vororar-— SL PERL O&O BAK AD Be
`) BEOMOMI MEM ARAA CL RR OPM RIB ZENG ORM SHAS CED CHE
`kw, LeMo tC, CNS OSMN EBRAHIM AAENK, KREME IA SS
`Vv PEPER T SOLS, HRA OW CHR EATS.
`C0013]
`CURR Pe OY VP POR ARBORS ke Baa
`CHOCLBMRT Se DOI,
`
`JP C1 G10) ROMA FMora-oy CiHTN) ®, EDCHHRMA LR AW O
`He rE(R ADR MIS CTD 1 SHR) lcm e 4,
`fooid]
`
`—WGE ULC. BOA OS Mie elo twC. AERO PSC Rw. MAIR. ASD
`
`WAL (ib MwA CE DC) BAMA YLRAM CHAI OUP FNR AR CTBT) Nm
`PurAyAmaaA er evM CP ROA). PFNfEE RP OFS hey CBHT) . ROR: ¢
`2-DLFUNE YW) FRE bb CDEHP) SHE) OBRRMA RMA CTD I MPD &
`LTO, EDCVRbH SHB, FRERKVPVEROM ES NICHE NAWILA MEW SC AIS
`DW CAVA POR AFR y PCEOM Ric bot. HA Lee, GBR Ik. Wie POM,
`
`mDpDBiHTNRG i PCR BU Z2HIE OWN DMR ALIS Alon od SRB © 4 ew)
`ROU RET ACR, PROOF a SP RCRA MDM eV ONS BRA St
`PEenicMe eH BOPROM LEK ARHOALCEA PMT S. HRN BMRB, RMS
`2tcg eo 4.
`fooi 5]
`AFSAAIE. MRE LEMIRE AT ZB ORM eo TP ORR BO Me Heo
`H
`& at
`Bot, ERMAVALY A?
`PF
`CH
`IO) # BAM Ha lc a ee
`SO, BEKO, 4 HG
`BEY BORIC MASBTEAR RE. “RARER 4S. Re Rice oc, YR Ae
`te. “MAMMA SH. CD38 26437 Mi ROU CRB ENA, ~ RRC Bw
`CT. 4 RUMP e SMe BMlicmAzAS’ ORK. ROCKS BAIL SB202190., ROA
`
`83 -OLDOLDUELE ROM COM RM e Bi, SMB lwo. HReE BS
`VAP AP CHT O) 1k. ORORMICL ROC KIASH ORT F CHAT 4. — RM
`
`BOT. SREbMAVA LY TPF CHI O)
`th, HORS HEPES MA Ci PSC) tHe
`C4, ~HMR Ric Bic. HRI PS ClE,
`U VOSSERR EE BAAD AO BS S BE Ee
`
`
`
`10
`
`40
`
`

`

`(8)
`
`JP 2019-506861 A 2019.3.14
`
`— HRB IC HOT,
`fd CLCL~i PSC) €U7YuUFSSYAFLELOCHS.
`i PSC. RAM HIRBROUSY ER RICE LIWRD OB SNR UP ATS
`PEtT RHGC BH
`fooi1i 6]
`
`dvUE a
`
`fa
`
`AR SE HATE. ABR kL 7 REE EHF SOS IA Hd @ OR Oe BON 7 GRRE ONG TE S
`NM { a
`HoT. ERMt AY TRF CH IO) & EMH lc aeeme way $3
`:
`ie HE
`oy aeABAL tcneee "SelleMiedo ce) MRNA
`SelHat
`~ SRB lcmzA Salo. CD32 6 MICO CHM SnD. CHIME BD
`GMM MIS MREMICMABCER. ROCKMMA. SB2Z02190. RUA
`SOL OLORR EER COMES GS — EMT Mlciw tT. Ame MS
`
`AY 4E CHI O)
`lk. PREORICL, ROC KM SM ORW A F CH RTS. — Ee Re
`CBC. SRE RWI TE CHLO) ik, HES MI Ci PSC) KEE
`C4, ~SHB Ric iwC. HSS Re AC1 PSC) ARE bhMaAL AY TP OCH
`1O) AND“ RB OP OF REY AROW nn tv Pr
`SUK XS YRN—BSA CWn et BA)
`O@e PCR BE SREP HM Fa Ci PSC) SIBTACLERMEAMANIKRE OAR. FG
`
`
`SOrkMCKLABBAORE, ERAD VERGE Fa-FORR, vRUPILCOE
`
`es
`Fo MB ERO. SNR RR lic wc. SRE ORI OM RE PA os A
`
`ne
`
`Sa:
`
`
`
`riHl
`see eee eee eee eee ee eat
`
`VAD TP EELS AHI OMM ROOECHIRG SOD J#Y. BURG
`cee eee ee wee, SMB Rep, MRR BK. REAee
`
`OR bay SBSH D ORIREN SL ODOM EOERR AR CRIT EBS Be
`RAPE BBR CF, 5 a MEME TE Loe HEU INU PRPHEL VY RPO AP 45 OTE. ROY
` ikrt
`
`aes
`
`
`
`Ela. THe Dw ee 4
`fooi7]j
`ARS HLL. ABROAR Boe 7 7 ORRCH oT. MSR. FARE OL ie
`Hoe SO. HRB SHR 4. SBC. SRR LEM. MELE
`
`Milly o5e 6RD> SRR ENS 1 OMEO Le MIDR CRT SB KEN TWA. — SEE RE lc
`
`PP A. BRAN op SR OR
`as, EMABB Ic $3 To, aea . RIN AAA.
`Bue. yeaa ie LENS a PU YW PEREL Vk FOL P 45 OVE, ROL ERE,
`HOGI O We GTS. —RMBRicwoOc. SMI . HAM lca Bee kee BIB
`aAvA/Y AE CHILO) RRL. CD38264+ RR HOU CHR HENS, — AM
`
`Bw CT. SME BAM AYP CHT OD)
`th. POF REV AROW nt BA MTF
`Ci PS CHRMBRPT Ar LICE AMIANIFH Oe RM. FGF ePEWont SAEKRUECHIR
`
`990 21LOOT RD EOE RCRA AIE Re Hig SC CIS ORIN O OIE. ER
`ADae PERM ERTa- TORR, VRUPNCOLKR AVP ERUMERF2a- 7TH
`MN.
`TE SOK. CHIRGO RD O2 1. SFY. ROEGCF ORE PF CHEB YT 4TE,L
`St Ake Kot.
`i PSCASBBRBENS.,
`foo1 8]
`AHAB SRT AVA POAPy POM. if POS HR OB Ra © Ae Ae ey
`
`Y/N eA. KEOAAMii, TCHOLGRF vy FORM, RMAOWMBReBL,
`Fil
`Ald.
`i P SMM ORHAN OIL PtP RP er YP OS YP) BAe EO MO
`Reidy Ss tl IP LR OR eRB AHS. THRPE, LEI, LEMP AG Sree
`
`
`
`REHASH OREN. LEM O- Mii PS CRIB MAR MLE Bick b Ow
`
`
`ee eee cit ee ee ORR otha Maino Le
`hetlc ho COM eENSZ, eB ic. CH SOME BMI. Hemera el OR
`LommePEABET SlCON TT. BRM le Uae. Eo Lowe. de Leas
`
`WH Ha 4 GF a .
`[oo019]
`
`26k, COPfFy Fk, BMS SHER Mee ce iy aa tn a
`
`
`Behe oS, CHE OILS MIM Ie DO. MA. OMA ML Awe
`
`
`
`10
`
`40
`
`

`

`(9)
`
`JP 2019-506861 A 2019.3.14
`
`
`BHD. CHK REANE
`[oo020]
`
`
`
`ACSEARLE. MR OMRM OF y PLEO DIE Mae HES SEO THOT. RY RR
`
`eu. WARM. LER ED BSH. CHER HE EK NEY. RHA OMMORIc, KE
`HA Sk. PRE AS, FRR SY MER RRS EMS SIM OMRROY RK ae
`
`WET SZCERRALKH. FCS, PAOW OAD, RIN SMH ROBO RS RIT 4

`LeSEA LL BOP ORR ABC bw. CNS ORM GABA, OT
`OE E R OG
`mCkoCRHEAL ROYER AMM BIBEE Py eee kot. MR OM RE
`
`SCL®PRBALE.
`foo021]
`
`Eh iP SHMUIBRICH RST SAAB B RAM CROMM) © MAES 6 1 DO ARR is
`
`
`MOM MHS 62MM ARATEIHA, LALEA GS. AMIR OHO Bic. Abe
`
`AMMMenoe ee Vo 7 FRR HATeS © ane tb aia &eckOH
`MivWtin Moo yah Chm . @HRRA) &. CNeEOMMe MOR R AOR
`
`
`hyo RAHM LK BORER pe CMA TT SZRM OAR OCORIP EMBL. HAW
`va. Eh i PSARIC RI SIAM SPER At. eR aic. RR TO OR
`Foy Pic M Le!
`foo022]}
`
`AHAB TRL AE KDI. RRB GEL Fy PA CIM LERARN EIBER
`Mig@e LTOEhB Caco 2M ROS. vr PaoRKRP RB ty OCU LER
`
`ER OMB ELM L CMBR BES. LAMICHT SRB eRT CL RRMRALKR. Lim
`29, CNEOF vy SCOMMIBD ROW MMO Ma. Cac oM#MORMM eH zs
`CHlAtE. “RSP AAS HE OAR. PV eK VAVV ECH LOBES RRL
`
`. TIAN MEER ESI RED RBM ROSS, Ric, WAS OF MICE ENE
`
`SEUCaco 2AM, Toe IS Ee RMD oe eM Om RM. ROY #7 tk
`7a-~-~YCHS. BEMDEL. BMY ELE RLM ROMS OST SHB AB RS
`ARRADHRAZCLEe—-OOMBELT. Caco— 2 MIMHRIS, BNRUY ROBB EE
`HERE PE OE PIE LCR BAX HTS, LAOLEA SG, RIEORSE OR CL Vt?
`DAH Pye VUbhawiwe lo. Caco 2MHR KRDO SR. Poe SB EAR
`SMTWSEMBRAE RO Bick< MEBAERLe GAD. Tv eR-Faradyyvy
`TIA AIO MM ER ERNST SMOSH A) . LEAD TL APA BRR oN TD
`
`
`
`
`tC. URSEPEIB ARR Ik, V ae Poway OCHA T BEL Caco 2M KO BRE OBR
`
`eee ee ate.eee ee
`kawe ene.
`
`foo023]}
`
`ATA MBSR TS SVT TOMA Py POM MI. BRUM Bice SC SN
`
`oo PEM OC. WME PLILLT Sc hb a. Hie.
`
`| pS coh seinem mye 4 ty
`
`VvoeOMmiaAP »y To. FRB. bbb. SIRI. ATES. BDA Me,
`
`
`We MTS, BOM OBB Rlo wot.
`
`
`1 PS HeES SRR ic HEI 4 Mes.
`
`
`
`10
`
`20
`
`40
`
`He OS A HET. BUR IER. RU- 7. BRR ROMIeEena nmmo
`TH {tae WN OD AN EK tH DD SOK S Be tc S CEB WILSIE EMS mo Amt men CI BOD
`
`1 BD St HOR @) A fn BR Ik, MICE REF 2 TORO D i BS ANE e EAE SS
`
`BoC.
`
`>. PLA. KR. WAI R, POV RR ERAT SAR BDOMA LES. LR
`
`
`ROMA LES. MOR DE. TBDRBOARMReL 1 PS MMO RICE LG
`Bo MOP OS MRM iC. MMR a. Mae. RM a.
`1
`RB DORKS
`7A. RR. RO ERA 5S HR ICIS LS.
`fooe24]
`
`AGM ECM TBF 7 TRIB PR OY AF LOREM ATES Tre Hae
`GIRS BS ait
`“Foy POC RR LTS. SALWR ERIE SATORED.
`Be IC 78 BR lc Seo % EISRWCeEE, HREM OM CRAM CHS. LEN OT.
`18
`
`
`
`
`
`

`

`(10)
`
`JP 2019-506861 A 2019.3.14
`
`OG 4 Werk we Bt be dB
`Re Bs Sinl—- APO MN e Alo C4 Fv 7
`KOKA SD PIE CHAD. PH) F 4
`PRR OOUE Re RPE LOR GL PAE RETR
`REM ShOO, MURR eRe ST ZF
`[002 5}
`ARB BldSP SV TRS Fe Pl. IRR EERO TMA ENERB
`
`CREAT REE RWS. mic. ad Wy fe BE Ze,
`¥ mEre ‘x fie i 2 #7 tt, MERE IK
`
`EOR BM. EO
`
`CM AI. He OBic AR TZ260) COMMEREL THO. MG ELT. wick
`RR ROR HAW, MA ORMEARS SED) BoB C8chKew
`W. RRA. MAM RDM A COMM DS OM. CREME EAM
`
`0 CORDRMM ELT. MALE ENEMA. FRYE, MIMI SLOT P S HOR ARG
`
`
`
`
`
`fo026]}
`1 PS CH HOI WB ME RO
`Solo. MA ERA vy Kl, HMoM, MAR.
`
`fd? MRSA. ROR T SIAM. MARL Uh ATY, Bee. TA
`
`RMEIWT Si PSCHROBMMOMAB ODMR OR DICH LHS. ZOKGRF VS
`
`SO REMMI HK SHA Ene eySPCOMMEPM A HCD OL Mme e LC. A
`
`
`
`
`
`
`‘kL Lodeee eee pee BACHE. HOMAL CHER a EH
`
`LRG It POM MID ERS SEDC MM EN SHED iP SMe ROH
`
`
`fem CEL PAIS, HREM OMB ERE HR LE BOL AY 5 OM HSU HS
`
`
`
`
`
`abet neBe We vein eatin a ond tithtto eet eon ih &
`
`
`mG ERT Sieh, HK, PRC ON MIA SRYOIR RN SSO fe BRO OM Ta
`RE. BMI MMP OVA TORR Pv PCCOMHN aE ERM tT SHORTT OMF.
`KH
`
`Bwoise, MAX NEV TORRPy PRB SAMBO T PS CRE RM ek ale
`rt
`MAES. BMRA D SMA Xe me. PAIS. AR. BOL 7 TP AR EL RE
`‘a
`REOWMORAPORBOMA REDD SA. CHEE TNE, EROL CA,
`fA
`HE LB R Bey Tek, PE. MEME OME TMB Se MMe EL ER Sle
`x
`
`RL eee ORR Oe. FPR ec ET SH RisaS.
`foo027]}
`MATE OW Ck EAC OM D TH SM. BSI KAORMOR DIMA EME. MAILE
`He RMIRe. MOR eR SHO MPM CHES. HME LCT. BZ1LAOBRBORD
`
`CBSE SC ew. WOR. MRL SPE RAE EL Wes. RL WINALL Ree
`RUWOG RM Ree¢rea kB RON SUSIE T SR MI BPHW LES.
`foo2 8]
`
`Foy PUR ANNE AEECHAR,
`AW MICH RS SV 7 7 OMI
`WLOMAT. RUKERARYNIRERBL, MRF RRARYNIRERAL. BF
`Al’, “RAF ERR YA GORMMIR EL) ROC. MESSNER EA
`AE. MRE TORO M UMEKi RBM O MME R SMR E HERR Sf
`
`
`KR CORNEAS.
`fo0o029]
`AMR EI. FV UE PO CHR OR SRM OUR RRS E PNET SHRI
`EPPS OEM ORMO CLIT, MRE RRB EP Vi, REY Oo.
`ROPRAOMMICMAST SZRYMUORM ARERR SKE OICRNA LK CIE M AH)
`kG T SHAM MRE AOS.
`foo03 0}
`Lit BoC, ~ SRRRR ICES WOT. ERNE AH RMT Si PSC.
`
` oFfont
`
`aS
`
`Se:HS
`
`Vis, Pe LE2DORBA EAH EH, ceneuko eo LOMA EN. Mw His
`RRP UCM DO OHS 1LOMELOMRFORRMAEKRE KK. MAM. Hero
`SESERD PS, ARON Fe AEET LWW, — IM th PLEMRO AEN 7
`
`|
`
`ix
`Jv AYP MRP TAC kRROM RPSSIAR ARK. Efe tk, Wap ES
`mi
`
`GFHSEDM. TEPSL vA YY VP RRR RABY OP DR ee COREE?
`LAE RISE HEAT Rk lowe) MAT STEKO, BHMENZIRTFOReMDEH
`
`PT RhHSBL Fae
`
`10
`
`40
`
`

`

`(11)
`
`JP 2019-506861 A 2019.3.14
`
`
`
`
`
`c. Re. WRrMRE OK. Tebb. FOAa-hEN, BRCHET}
`SRBC OR® CCRISPR) MTHRBWeTmR IRENE EORROL oY EO it
`BLE TRH KS. LYLEAS., ~RMLIEWED HET SPD i, RBA Ca L&R GE
`
`PEM LOHR RMAC LC. A ARO STR (CSR eR ST Mle,
`foo3 1]
`LCheMotC.
`
`-Si RRBbee. NOOBS BE Tei PS AE eee eS
`
`VASA TROP LicAP SOR BL COM Atc KG ABBE SEI TRAH Hel © ee
` Machm 6H OMS, BPOMORMB Blow. RHUL NANVeB SRD
`
`iC. HiT eM CRMMSY STE, » kaERMEM EIR OR OME
`EMT SR MITA, MOD ORM Mic jet, MN VIATOR AF vy Wich e
`SHAMI MEER GURAB REN GS, WORMRK Beet. Vt ery PML
`
`lc MIDE EE ELEM ERELS, BODOKRMWEMICBUOC. MEFEMETS X
`
`DH. MAW. WRT LE OR MIC, MAOP LY ACHAKHEDNADSHRE
`
`10
`
`ne MMe SOMONE Re EA Bin FM ws LO ke
`
`Hic, RVINSVRARMB ST S6HHOORKRDNANRN DT R-ERGRNA SAHICRMA TA!
`fo03 2)
`RW RR CBT. BDO DOAS IL OD LOIN( FROAAP BAB Ree PS CH
`
`we
`
`
`JIN MIAO PLS Wd MM D> DBMS Sb OM MMO RM e MEMS BRCM
`
`NS. ROR HI, PAR. WHER Si PSCOMAHEMRBA,. BOOBS 1IOME
`OWE CARER ROMOMEN SR ERM CIR GN EY Re A CHRL ES
`® o
`
`
`
`[0033]
`
`
`
`AWB Cea STAY TORII Pe PL IPR BOS PE OO
`
`epM Cio, 4YRIMBE LC. APN SIE Rebee Mea, MORROW ORB
`Rw. TebbB. [WROTE ROWE EA OHER ES Slom LT SHE Ae
`
`PEAT SN SD. CH BiCMBe NAY, WAIL. ASEAN OBE ORR IC.
`TE BE ie te
`CBMI<25) ROBMI> 50 O78 FB CSO) ESA SN EZMAD SD
`i PS CHR
`
`
`“RRL RWC. Fu PCRBLeE, CHE OVW 1 PS Cl. ADPWMM- BB CG!
`) ANALY TR ROMR FR CHT) ta - OAD FRPP ae -—OVAORD ECHO
`
`
`HEE PU V 4 7 RF ye DICTST SMI BA Le. RH 3G
`
`1 EBX NY
`
`fog LeMo Te, eee ee ROLE REMM bomen ee
`PENS DMRC DT.
`IP SCANTRMED SNES RODSTa kT
`TN) Aoi PS COSPUI.
`TAR AR Fy OY Va RAR IS
`lc Ae RRS OS Atc
`
`Draivetem le. WILBAVAY PR Ci GIO) ROMA FRoOa-oYy CiH
`
`Wonk.
`[003 4}
`ACH AH Bic ac RT SKDC. VA VORA Py ik, Rameybic, BAY Ge
`ima a veeo, PKG Rea HOV ELT.
`1 PSHE ROTEHH CMA IRL BK
`MUNG) ORT BSAA, MEOeA POMP IRR ENB. LeBow, BODOR
`
`cone eaeeee eee > Mapa
`QVM BR to bwoC., 2a oY el. Fy Ve SHR OICH RCMLBS,
`X
`Slo, +HNSRAMBLR Fv FORRROAHE., Sa oYete HE Nie RHO Fy
`
`RW ECO W— AY HIRO BME RUF.
`{oo03 5]
`
`ARMIES GE ES SD Ie Foy PCM T AcmeeMeR SCE SL ME
`
`
`REORE OFF b Re MDA eS SAS ER CANS) CRT SR PANONS
`AS SS A OG FEO BR tC LAA BaND The PE NLR OR BIE CC HELO TL EAR ANU bY + RE
`
`ee yD Tt Foe THE © 7 8) Ie E-A PNY VGRIRW-— Am % AOC A ee
`ime ak fAOBRMRe AT SMM et FR SOL. UC. MERE e aT STE
`
`
`
`SnERS OP OR AeA T SCL eR UR. Fol, AVIS eRe Bm 5S Oe
`
`40
`
`

`

`10
`
`40
`
`(12)
`
`JP 2019-506861 A 2019.3.14
`
`
`
`
`fa 2 IRS SEM ORI RS OM AD. SME REO REPRE RAROLKR SHE Se
`
`
`
`ADAG SR eH LLLyy PIC HEM CR ZTE PHA ADK. Lica tT. HRM OE
`Hitk, FAR RRP Ar PERERA BATE DS CRSA,
`(003 6]
`
`
`
`
`
`
`Hal N
`
`4p
`
`
`
`
`
`
`
`
`FEBS —W RE Ic Bvt. Me RT ARR CHOC. a) kLMLRm eee
`CMmAR GM eter oc EL b)
`i Q S Bae i Hal 4g bm k eid Face
`as WR wee
`Lcq.
`. Be ) aK HR BS 1 7e A AY ih MS Tie Ad eR OY Ere td He
`fe
`a EIU BREECH RYDE LESS. 4a mhe PMS.
`e eec
`fa bt
`Bu.oy FmAH Hk BO fe 2 A eRe Ib a ee Ee Ae UR
`
`
`
`WBE ERAN RM6S RP GRR SS, SERB BR ic del, PRE hfe Mid ON
`— BARR. AAT. ROY E elke ACE SETS.ELS RE Clk, HR
`tH aie
`WH 2. PRES CE PO CHP RT SB. RETARD. BRB OMB SHR. Eri. MO fe
` EEGkGEEE
`rs
`eera
`&
`> CER eS So klk, PM EN TOY, — SR Relic bw co.
`i
`OP
`OS RE
`4sRt
`“4bMICHEM UL. AAR. ARMM ER 2OR POMC RR ToC Ee
`
`
`
`ai, Mie eM Se Mic, RA ASM PM SNS. HR RR ice.
`me SRA. ISI 2 CUR EL ic iA UAB AIR Ee tee LC.
`OK DORSAL Pe SE I
`Biox
`co RY_
`GiNR ¢ ah
`cas VC. RMS DEM HI. BM, RU YER ESO BK DS ABB Ic FE LU
`RHRBlog Sf oic, CHM) MOS RMA SHRENA, COT RERS
`
`Hic. MMA MK MAI, SR REtc Bec. AL AY PR ee, MRL OER
`HENS. —~HMw Bic C. BIR UL fe As. BSB a EM A a. (8SA Fg.
`ROGER BWS Ae Bi. PVA LS TP ORAL Be PS BAL FE
`LOE Ric ist. Sma DAY TP. cbRe he PEMic ORT SO. AERA AS.
`
`BIRR, PPA GAL KK, MMAR ko CMR ENS CER, PEM EN THORBL,
`RT RE ICS OT LIN TA Hm eA) OB Re GESG A RBIc
`x
`wee
`
`nade RES tive MPA iS. BEIR GR eA LOC HRT AY TRORR ETS. RE
`wy
`
`ov o SORE AB lo CL SR TR OPEy ee id . oi Go) ake Bh od, — Fe hie
`
`<“~
`
`
`
`ee PILE T S 7 ONS AIEEE CS BS ee Bc — RR HABRC As Wie
`ER
`HB Tk
`
`“RAMA SY TP. SMe ee Sore bh RB RO MS SEMIC RS
`> SEAM RR lc BLY TY 4G ABI He TERR Mk, REE ER CL BD) GMS tr
`
`CRA BT 4. SRRBCL MS RETR Ml, AM RE ei Si
`
`RB ICH RTS. MBIA. Pi MOM ARU DESH 6 CEM CES, — SIM Ric
`N
`
`IT
`mB PRIS, BUR eASE CR RN MeASC kee i.
`By ik. BS AA Ze MIi Le0D TEWBHES B. — SEM WERE Ic BLY TY
`JB Bei Buc. YE
`
`
`
`SRDS. BACAR AMER SOLES SCRE. COCKER, BLOKE
`ra
`PPS TER CES. ~RWBRebwWT. SREeMa Ab ik. TE ER #ltc
`
`So RMB RBC. Sa BIA MRT Re GBS AE Po +e
`Ko CRH SNe
`lOKko CMA ENS,
`0037)
`
`bRHOKGIC, YR
`Wik,BPiOorr AVOR Me we Ll, BOYIk, OB 2
`Wet. YR WOM RE
`Ory BW Ob th # ih
`
`
`
`
`a. eA ke Hic Ae Zc EDCeXeA, —BMB Bloc Bec. 4
`oy fh 2 RE AS Re OF SR A
`we FT
`Re R. teh aay. ROYER MME OMAR. MIS. BL OD
`why
`x
`
`“MI e RS PSC LR EGR RO, HRB BOT. MeL 4K
`Ad #
`Ip MN & eet SS. MA GAPE OERWEM SV A-SOWP HA) ele MM & eh
`
`Bilk. WC DPOAK CH RMT SOE ACor —~— SeAS RE IB
`wo 4., AHA, thio MM eRe x AB o bLiePpMl TBS
`
`

`
`t t
`
` HeerflEL, TCHOSOMMONAER OPW easel Fr 4, FEGll., COT, BY
`
`REC od 4, — RRR Bio ib wC. HAR SM lc UOT TR BOG EI A 2 BR
`LRG aL, yw fA RRM ERE BAe hi hOL PHN KAHL EHNSG
`2 i Rs Ht APES ODA ADARE G4, MAT. COT LI, MMe eA Ree 4
`REI WT, MH HE , AAP TIL ARMAMR T SCE RE SMEG.
`
`SE Ale Fz
`
`
`
`

`

`10
`
`40
`
`foo03 8]
`
`(13)
`
`JP 2019-506861 A 2019.3.14
`
`
`A S8RAIK . GRAS ASG OO) ew A eT SCL APM SO. CRE Ric BOT,
`“4B MIR. VHA CHS E-DPRNUY SHS SoS, Rie. KRISH. aS.
`
`
`ay CALE. Porat, ih wel H&E ) RAMI AS ve ee ~~ SE ig 7BE ic
`
`
`Wet, BAM, HMRI ESM A CER. Ph APY) OMEAMH TS A
`Fu Tee ICA,
`[oo03 9}
`
`
`
`
`
`AS FE BAL bk AE IT OB OW SETS hima 2B SO. ARSENAL RP RE OY
`SWIM eT SCE RAM UT 7 LY 2 RMAICT. ARR AP y Fed ts
`
`Oi Ck S40. KO-MMeIT BIL Rei.
`1 ORM, ERG, Blo, 148
`Md. Rfetk, CNMKLETDNS,
`
`fo0o040]
`
`
`mM
`
`
`LA PRT AL
`AREA E. RAMU Ee MT Sr M I HIC RNS PBA TAC
`
`
`ARPS RRC Btwooe., ERIS RRL. LORE OMS COAIRL YF Y. EGFRE)
`HH ey TS y
`foo41]
`-~ SHI RRC Ct. SARE, be
`IRAE, WC DD OPM eA LES.
`S<KERLDMOAOKR-F+FROVRA SC LELTDOUOKR-beE SOR BAL Me OY

`RBATBR- hOGA DIUAA,L ELT, HRMHAOR- ASHE NA
`{0042}
`oH
`
`
`
`
`
`LeROMAR ON AT ORABRBRAH RT 6, b) BMS Ne AMER ETS
`
`fe. ASHEHR IS TB Ric OT. Meee 4S ee eee
`Sic. 4 Lito, BM tate ko AT LHI TRAM OSE. 0) NIAMS
`tite Mae. HS HRY. HA eH ho Rtn ic eRe
`OC) RS he aes
`ee
`Low COMME RS LLC ES
`4RMaAaNwTS 7 Me ARO YE fe td Me He
`.
`
`SlL¢CeSRe. “RAMS PRT 4S,
`| RA
`o RHBic BC. 4RIB Ask, HIB©Iba
`PES AEA. PUR OME bee Mio, RO
`
`BROWS LRH MAORSHR MY ORRENSA
`iV fT 77 FOR AS TBld WC DAO RH
`ARR CHAIR. LODRY RV. 2OOF¥?ma 32MEOFV AM) EHTS E
`
`
`
`CNC E Oe RTI EI BNC. AN 7SRABBI. YRIRO’ MEE
`ST ARBLO VA FORA Fr pe, 4 6 WE OD 4aT LHRSS B20v7 FU
`MG VAVEREH. SUMIRUMZOV IT ORES + RVOSAR. SRMRICH
`LCT kMERAL DO, MIRE eG. ARIE HAL V4 7 TK BE EA © fe FE
`
`FPA QO Mei Mae en eazckLePM UCB EOS,
`CB Alcan A CT) AR @OBee
`
`WATEMEESA, Te HE Hc BY tC. SRR PRmo ae OVP ERB 2OVAT
`
`with Fv BIWHS}S, ANE OMOM ED KREMER, — SE Ab AG BE IC Fo Ws To
`. SRR Poa OV HERR 2 OV TT ORR Fe RN OR SGMH ROME CORE
`
`ey
`EES USAR AGRAPCHER ST
`
`4 ™
`
`SHNwiE=oe
`
`LO. wae Re ae 31cm S, TCOCE. MHCHEER. ECNHAO WMA) as
`# fe td . cs wana ‘dL VrA-CHSZE-ARAUY HHT 4.
`
`=(et
`
`o~
`
`. BU NAV ARK ERT SCRE NBME LY, KRMRic bot. HRI Mm
`
`
`
`foo43]
`MD ~ 7 7 OKA CORRS SBC. RRA CEH Bic KOC. BBR eS
`Re 24ckMED tT. HOR-—b PSA CERI, MBER) FeiVT arc em ES
`CT. ERG. OWCH, BRBO-MPe MECHA TSA CURT 4. AGATE aT Ss
`
`nk
`SE) CkM KOM MT SCE MOCK ACL APM TS, PELE He Rei OY
`
`
`BARI. SRA LER B2OF VY ANAMRUC.
`(OS Me REL COKERR
`fae Pic, HMAEAR ICR CRRA RSI) HEM ARES SAG vy PR
`X& Htc BIT,
`(o0044]}
`ASEM Ik . MENGE T ARMOR CRP Oh IKE MSS, AR. Roe
`
`
`
`

`

`(14)
`
`JP 2019-506861 A 2019.3.14
`
`PMC IRE ST SOCK BRUT RY, KRM BRC. RBA Py Fo) lL Db
`
`
`
`
`
`mC tke AAR. KO-MBMI 7 AM. K7elé,
`1 OAM BEAK.
`€5t214 Al,
`Rfetke abirpna,
`{0045}
`
`b$eOKG i, HRV PFOA BL OC DP ORAROR BZA LEA. —- 2h
`Weel BOC. HRV AT OWARR A. PEC LELTDIMAR-—FROUDRC LEI
`
`DOUOAR-he€ OGRA, HRIRM IS. BRAD H-RYSADOMAAL ELT. SR
`HOR bk YoOHKENA,Y
`{0046}
`WMAL A/T Rev ae PARRA NSZTEDCEAA,L HMC, Misea VA
`JOR PSR ESE PCMHTF STREP ELY. KSlc. PM OMe RIL BY
`
`L (MAW. FACS @#(RWLOC)
`. MT 4D, SERN, 4HRANALS AES
`Pe T SOLAS. RELY, — SBR lic tw co. BRAN AY 7 ORABA Am D7
`KP SMARE Di, MIS AT. MBM Me. HAMA. ROS ERS WR
`
`
`
`Mifd# @ts, -SeMe HR ic BwloeT. HYMAN AY PL Eb ROR SREP SAD So SS
`
`2S, —SR Relic BWC. SRM Ste Mid. GRIR GRRE ALOT Ha VAY a
`
`BPO GSI Lic, ~HRMBlot tC. 4MIPM A NeW, BIR ROR eA THEIR L
`
`fe. AFv Fb) OW. MRS 1. ARR OL RCL RR Xe. PR. RA
`AQ, Bear. Kfelk, 2NL LOMA aPae CHA,
`{o0o047]}
`“MEV ATOAIS, RRMA T SRO N TS SCELD CES, — RMR
`
`
`StONAE
`
`
`
`10
`
`bh AH OK © HOM SAE LEMIM I
`BWC. HRA ASL A ¥ ke. Be ee BMSSal ie ke
`HRY 4, Se peamtmtt ST LeEBM TARO CSR RWAD. —SWH Ri BT
`. 4aSsRE TE AE Met REE Mm CI BD) &@MS NE RAK HRT S ,
`WEMC Dit, NOAM SIMU E. KILDA NEE eo
`
`
`
`tL Ob hos
`
`[0048]
`eA RE SeSR EAS. PEE NS. ~RMWE i BWC. Smee,
`SAA CMA ISL 2 EY EGF#2#) #8,
`{0049}
`WYO) SE ARAB BE Ic woo ARSE BA MD
`
`riTS
`AWAY 7 RRR OG i) Limb meme & 2
`e) “RRM E ne MMe. BAWic bk o TH BIFM OR Nik MR Be MO f
`>) 4m HERES AMIE “a MEGR L fe MPH 2 MRR O YER UMN EDIE EU SER
`FE RP CIT SCROLL HMATAR PETS. —- RMB Ric bw. Hm ie mw.
`iBNOSA HE AB OD Hh RESMH. ROBB OUIRS | emf5&4 5 eR
`
`
`
`&. b) 4mAN AS 7 EF Ree BIR aR Ric HL OC EIR Lie Me ee ERT SC EL Cc)
`
`“4 TR IR Le We RR LOT PP eo Soe d) 4ARRRIR LRA, BRA LOL PBR
`
`Lic MHP OUP RANA KGRHRV TT ORMARBOYNBRIROMMEL MRM TS TE
`
`
`SnN4, RAB RHRRA PM SNS, H-RWR CBee C., SV TOO A RS
`4. 4YRROYMRLA CRB TSR LON ATOR ve REL BOY eR
`CRABB PT SB 2OVA TOMA ye AN Ee BA, HRP IL ROR 2 OV 1 7A
`FraAVOSBRIL, HMBC LC POEM eR AL DD. BRAM Se Bt, COA
`
`
`tk.
`PRMD He Pla eR ST SB hie EN BOMBA LTR, RE RR lc BOT
`. RAR PB oa OV AHR COVA TORAP yy RANI HBS, CNH O AMO
`
`
`
`40
`
`2COAVTDAPORAFR y AVOCA MROM BR OME LCL MOH RAY RAE RE SEB IC
`
`
`TRE OM ICRRE Ste, -RMB ReBCL HMR FMB oa ik, 4Gue
`® « BON TAS 9ETS SHBOED CXS. —FNRelic Bloc. Neim
`
`, VO A- CHES E-ABENU Ye RST SO, RAR REE © AE RC RIC ER RE NETE
`
`EM ULCHE OP. RAL BOR. RT AL EOP MAN HE CHS, ~HI IRE BlOT
`
`AFuPeo) COMBMBIRL Mao 4 Mie, bere 1 > HM pb AS.
`[a] Be
`
`+(
`
`tS AR RON TZ ORR E REIS & &
`
`TIRE ST OATE EC HoT. a) 1) GRAN AG OR
`
`

`

`WA A/T Pik, BS eee ee Ee hic RS SMS EM MINE HEP S!.
`
`
`
`MS
`i
`ae Wr X ft ye BR
`SRE RR IctoT. SME SRE SA, AEE RR CT BD)
`
`BlcmRT SoS. —~RMIBR ic BT,
`aki Be PETER RN AIS ABR & ORD i XK 1 fe BS
`HRT 4, RMR BOC. HRA A AY AP, Re RT hie
`Sst
`a
`HRS See te Pee Mcrae 4S. ORI Relic loc. “RAR.
`SO KD
`
`
`(15)
`
`JP 2019-506861 A 2019.3.14
`
`ma MAS TRU, See ce Knee bh ICHR ES WE ETEURS POR
`
`jc. ASEH.
`DO DRSRMEA CIGBINR RYE N STEEDS. BM SFO CWORW, Shi
`RRC. Ary Yi) CO“ MIB. beck AAIN. FO-RNicCK 7 AT
`
`
`
`
`1 4AM Leo CRM ENA, SRY A 7 OAR iglk
`. £fetk,
`1 OAT, Elk.
`_ S5RARM ERT STE A CHS. MAI, ~BRR Rice ct. SRM1 7 BA
`
`Hels. be CEB LOMOAOR-—hRRODR SC ECL DOMOR-— Lh eSSEIBAL
`
`Mm Hik., SRAM R-RYSAOAAL SRO R-hFPOH ENS
`[oo050]}
`LHOKDIC., BARKS OTC OSH Belk. b) gad tol AY’ 7 ORORDA 4 BER ak Bic
`ULC, BIR UMA ERS STS PMP 6, MRR coo, HERR Lie
`
`Ait. GB ATER MH. PRR ERA, MOYER URI RRA ee Bo, SE Re ic
`We. SMa A LPG. che ARETE MRT SO, Ee Relic ise tT. 4
`
`
`~~ hen Relic ws Cl. HRS SAMA. CRE PRI RR CI BD) &#m en
`&.,
`
`
`RRR IHR ST S&S. HRMRR ICC. SMA SAEPER MM. AIRE ewe Tie
`
`RIC HRS 4
`foo51]
`ad GAM SHEE AI Ci PSC) ®,. Bia
`SSlCM OR Ric plc. RSE.
`
`HAPY?PF Ci GIO) OALFo Y Ci HTN) WR EOE EUVACE.L RH
`5UtK. b) SEMIN CIRPy OVP ORR RB LIT ATER ROKR REE
`C4, ~RMRBR lc pwc. HRAAYPI RR ee. PAR, ROSY
`
`# 7o tkARBK A Re ete EB RB ic BOT. CORR.
`oc) 4M XS 4 fe Mie
`Z, HRA VA/S TR ROM MMS eA eR ROY ERIM & oe ©
`SCkrPHO ARMS PR CIR YT ST hke, CHM So, HMR it. Amst
`
`
`A®W. SMR i ilweoC, Me. HRA TF OGRIRL, mae aL PRY
`
`EC. AF vy F bo) OMIM L eH, COTE. RABRVYI VOR ARERR ORR TEM T 4S
`n
`
`o ~ RMR Ri iwc. HRIPy OVPOR AIS. LM

This document is available on Docket Alarm but you must sign up to view it.


Or .

Accessing this document will incur an additional charge of $.

After purchase, you can access this document again without charge.

Accept $ Charge
throbber

Still Working On It

This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.

Give it another minute or two to complete, and then try the refresh button.

throbber

A few More Minutes ... Still Working

It can take up to 5 minutes for us to download a document if the court servers are running slowly.

Thank you for your continued patience.

This document could not be displayed.

We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.

Your account does not support viewing this document.

You need a Paid Account to view this document. Click here to change your account type.

Your account does not support viewing this document.

Set your membership status to view this document.

With a Docket Alarm membership, you'll get a whole lot more, including:

  • Up-to-date information for this case.
  • Email alerts whenever there is an update.
  • Full text search for other cases.
  • Get email alerts whenever a new case matches your search.

Become a Member

One Moment Please

The filing “” is large (MB) and is being downloaded.

Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.

Your document is on its way!

If you do not receive the document in five minutes, contact support at support@docketalarm.com.

Sealed Document

We are unable to display this document, it may be under a court ordered seal.

If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.


Access Government Site

We are redirecting you
to a mobile optimized page.





Document Unreadable or Corrupt

Refresh this Document
Go to the Docket

We are unable to display this document.

Refresh this Document
Go to the Docket